Title Prof. First Name Swati Last Name Saha
Designation Professor
Department Department of Microbiology SDC
Email ssaha@south.du.ac.in
Webpage
Phone.no 24157380
Employement Info
Employee Type Nature Of Employment
Teaching Permanent
Educational Qualifications
Degree/Certification Name Institution Year of Completion
Ph.D. - Ph.D. Indian Institute of Science, Bangalore 1997
PG Sri Venkateswara University, Tirupati 1991
UG Sri Sathya Sai Institute of Higher Learning, Anantapur 1989
Fellow Academies
Fellowship Academy Award Name Year Of Award
National Academy of Sciences India Fellow 2021
Teaching Experience (Within Institution)
Designation Duration
Professor 21-10-2011 To 30-09-2022 (10 years, 11 months, 9 days)
Associate Professor 11-04-2008 To 20-10-2011 (3 years, 6 months, 9 days)
Reader 11-04-2005 To 10-04-2008 (2 years, 11 months, 30 days)
Administrative Experience (Within Institution)
Designation Duration
Dean of FIAS Presently Working since 16-09-2021 (3 years, 8 months, 7 days)
Head of the Department Presently Working since 01-07-2019 (5 years, 10 months, 22 days)
Administrative Experience (Outside Institution)
Designation Institute Duration
Research Associate University of Virginia, Charlottesville 01-11-2000 To 16-07-2004 (3 years, 8 months, 15 days)
Research Associate Texas A&M University, Texas 17-11-1997 To 31-10-2000 (2 years, 11 months, 14 days)
Research Supervision Overview
PhD Scholars Supervised PhD Degrees Awarded Theses Submitted
6 11 0
Research Publications
Title of Article Type of Publication Name of Journal ISSN Journal Volume Year Link to Article DOI (Digital Object Identifier)
The SET29 and SET7 proteins of Leishmania donovani exercise non-redundant convergent as well as collaborative functions in moderating the parasite's response to oxidative stress. Research Papers in Scopus Listed Journals Journal of Biological Chemistry 0021-9258 301 2025 10.1016/j.jbc.2025.108208
The SET7 protein of Leishmania donovani moderates the parasite’s response to a hostile oxidative environment Research Papers in Scopus Listed Journals Journal of Biological Chemistry 0021-9258 300 2024 10.1016/j.jbc.2024.105720
The extremophile Picrophilus torridus carries a DNA adenine methylase M.PtoI that is part of a Tyep I restriction modification system Research Papers in Scopus Listed Journals Frontiers in Microbiology 1664-302X 14 2023 10.3389/fmicb.2023.1126750
Histone modifications and other facets of epigenetic regulation in trypanosomatids: leaving their mark Research Papers in Scopus Listed Journals mBio 2150-7511 11 10.1128/mBio.01079-20
DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in Leishmania donovani and the Cdc45 PIP box is essential for cell survival Research Papers in Scopus Listed Journals PLoS Pathogens 1553-7366 16 10.1371/journal.ppat.1008190
Cell cycle stage-specific transcriptional activation of cyclins mediated by HAT2-dependent H4K10 acetylation of promoters in Leishmania donovani Research Papers in Scopus Listed Journals PLoS Pathogens 1553-7366 13 10.1371/journal.ppat.1006615
Histone acetyltransferase HAT4 modulates navigation across G2/M and re-entry into G1 in Leishmania donovani. Research Papers in Scopus Listed Journals Scientific Reports 2045-2322 6 10.1038/srep27510
HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani. Research Papers in Scopus Listed Journals Nucleic Acids Research 0305-1048 43 10.1093/nar/gkv431
Characterization of the MCM homohexamer from the thermoacidophilic euryarchaeon Picrophilus torridus Research Papers in Scopus Listed Journals Scientific Reports 2045-2322 5 10.1038/srep09057
Characterization of the replication initiator Orc1/Cdc6 from the archaeon Picrophilus torridus Research Papers in Scopus Listed Journals Journal of Bacteriology 0021-9193 196 10.1128/JB.01020-13
A highly basic monopartite sequence at the N-terminal region is essential for targeting the DNA replication protein ORC1 to the nucleus in Leishmania donovani. Research Papers in Scopus Listed Journals Microbiology 1350-0872 158 10.1099/mic.0.055640-0
The histone H4 lysine 14 acetylation in Leishmania donovani is mediated by the MYST family protein HAT4 Research Papers in Scopus Listed Journals Microbiology 1350-0872 158 10.1099/mic.0.050211-0
Characterization of Leishmania donovani MCM4: expression patterns and interaction with PCNA Research Papers in Scopus Listed Journals PLoS One 1932-6203 6 10.1371/journal.pone.0023107
Kinetoplast morphology and segregation pattern as a marker for cell cycle progression in Leishmania donovani Research Papers in Scopus Listed Journals Journal of Eukaryotic Microbiology 1550-7408 58 10.1111/j.1550-7408.2011.00539.x
The distribution pattern of proliferating cell nuclear antigen in the nuclei of Leishmania donovani. Research Papers in Scopus Listed Journals Microbiology 1350-0872 155 10.1099/mic.0.033217-
Expression and subcellular localization of ORC1 in Leishmania major Research Papers in Scopus Listed Journals Biochemical and Biophysical Research Communications 0006-291X 375 10.1016/j.bbrc.2008.07.125
The promoter of the Chinese hamster ovary dihydrofolate reductase gene regulates the activity of the local origin and helps define its boundaries. Research Papers in Scopus Listed Journals Genes and Development 0890-9369 18 10.1101/gad.1171404
Cloning and biochemical analysis of the Tetrahymena origin binding protein TIF1: Competitive DNA binding in vitro and in vivo to critical rDNA replication determinants. Research Papers in Scopus Listed Journals Journal of Biological Chemistry 0021-9258 276 10.1074/jbc.M106162200
Three different proteins recognize a multifunctional determinant that controls replication initiation, fork arrest and transcription in Tetrahymena. Research Papers in Scopus Listed Journals Nucleic Acids Research 0305-1048 28 10.1093/nar/28.3.843
Allele-specific protein-DNA interactions between the single stranded DNA-binding protein, ssA-TIBF, and DNA replication determinants in Tetrahymena. Research Papers in Scopus Listed Journals Journal of Molecular Biology 0022-2836 295 10.1006/jmbi.1999.3365
Functional analysis of conserved motifs in type III restriction-modification enzymes Research Papers in Scopus Listed Journals Biological Chemistry 1431-6730 379 10.1515/bchm.1998.379.4-5.511
Mutations in the Res subunit of EcoPI restriction enzyme that affect ATP-dependent reactions. Research Papers in Scopus Listed Journals Journal of Molecular Biology 0022-2836 269 10.1006/jmbi.1997.1045
ATP hydrolysis is required for DNA cleavage by EcoPI restriction enzyme. Research Papers in Scopus Listed Journals Journal of Molecular Biology 0022-2836 247 10.1016/s0022-2836(05)80137-8
Research Projects
Project Title Project Type Year Of Sanction Outcome/Output Duration
Towards identifying parasite-specific proteins involved in DNA replication in the protozoan Leishmania donovani Major 2022 Ongoing since 23-08-2022 (2 years, 9 months)
Characterization of the functional role of SET domain proteins SET2 and SET3 in the protozoan parasite Leishmania donovani Major 2020 Ongoing since 14-02-2020 (5 years, 3 months, 9 days)
Investigating cell cycle dependent gene expression in the protozoan parasite Leishmania donovani: a genome-wide study Major 2019 Ongoing since 06-03-2019 (6 years, 2 months, 17 days)
Investigation of the roles of GNAT-family acetyltransferases Elp3a and Elp3b in the protozoan Leishmania donovani Major 2016 21-09-2016 To 20-09-2019 (2 years, 11 months, 30 days)
Investigating DNA replication protein Cdc45 in Leishmania donovani Major 2015 08-10-2015 To 07-10-2018 (2 years, 11 months, 29 days)
Investigating the roles of SET26 and SET27 in the protozoan parasite Leishmania donovani Major 2024 Project has just finished one year, two more years to go Ongoing since 20-02-2024 (1 years, 3 months, 3 days)
Investigating the functional role of Leishmania donovani SET21 protein Major 2024 Project started four months ago. Ongoing since 20-10-2024 (7 months, 3 days)
Talk Poster Presented
Name of the Activity Role Date of Activity
Investigating epigenetic regulatory mechanisms in Leishmania donovani. Invited lecture given at the BC International Centenary Conference: a celebration of excellence in research and teaching, Indian Institute of Science, Bangalore, India Invited Talk 11-12-2021
Towards unravelling regulatory epigenetic mechanisms in Leishmania donovani. Invited lecture given at the International Conference on ‘Epigenetics and Regulation of Gene Expression in Kinetoplastid Protozoa’ organized online at University of Glasgow Invited Talk 30-06-2021
DNA replication in Leishmania donovani: towards finding new solutions to Leishmaniasis. Invited lecture given at the International Symposium on Sustainable Health 2021, SSSIHL, Prashanthi Nilayam Invited Talk 26-03-2021
DNA replication protein Cdc45: uncovering new facets in Leishmania donovani. Invited lecture given at the National Conference on Frontiers in Biotechnology and Bioengineering 2020, JNTU, Hyderabad Invited Talk 16-07-2020
The role of Cdc45 in Leishmania DNA replication. Invited lecture given at the 60th Annual Conference of Association of Microbiologists of India, Mahendragarh, India Invited Talk 16-11-2019
The role of Cdc45 in Leishmania DNA replication. Invited lecture given at the 60th Annual Conference of Association of Microbiologists of India, Mahendragarh, India Invited Talk 16-11-2019
H4K10 acetylation mediated by histone acetyltransferase HAT2 regulates transcriptional activation at different cell cycle stages. Invited lecture given at the 59th Annual Conference of Association of Microbiologists of India & International Symposium on H Invited Talk 12-12-2018
HAT2-dependent H4K10 acetylation modulates transcriptional activation in cell cycle stage-dependent manner. Invited lecture given at International Conference on Innovations for the Elimination and Control of Visceral Leishmaniasis, New Delhi, India Invited Talk 30-11-2018
Transcriptional activation mediated by HAT2-dependent H4K10 acetylation in cell cycle stage-linked manner in Leishmania donovani. Invited lecture given at Genome Biology 2018: Mechanisms in health and disease, Bangalore, India Invited Talk 14-07-2018
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