Title Prof. First Name Amita Last Name Gupta
Designation Professor
Department Department of Biochemistry SDC
Email amitagupta@south.du.ac.in
Webpage
Phone.no 24115270
Employement Info
Employee Type Nature Of Employment
Teaching Permanent
Research Publications
Title of Article Type of Publication Name of Journal ISSN Journal Volume Year Link to Article DOI (Digital Object Identifier)
Repurposing Novel Antagonists for Targeting p7 Viroporin of HCV Using in Silico Approach Research Papers in Peer Reviewed Journals Letters in Drug Design & Discovery 1570-1808 19(11) DOI: 10.2174/1570180819666220124112150
HigB1 Toxin in Mycobacterium tuberculosis is upregulated during stress and required to establish infection in Guinea pigs Research Papers in Peer Reviewed Journals Frontiers in Microbiology 12 doi: 10.3389/fmicb.2021.748890
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors Research Papers in Peer Reviewed Journals Nat Commun. 12(1) doi: 10.1038/s41467-021-27275-8
An efficient ORF selection system for DNA fragment libraries based on split beta-lactamase complementation Research Papers in Peer Reviewed Journals PLosOne 15 https://doi.org/10.1371/journal.pone.0235853
Emulsion PCR made easy Research Papers in Peer Reviewed Journals Biotechniques 69 2020 https://www.tandfonline.com/doi/epdf/10.2144/btn-2019-0161?needAccess=true https://doi.org/10.2144/btn-2019-0161
In silico study of chikungunya polymerase, a potential target for inhibitors Research Papers in Peer Reviewed Journals Virus disease 30 2019 https://link.springer.com/content/pdf/10.1007/s13337-019-00547-0.pdf https://doi.org/10.1007/s13337-019-00547-0
Virtual screening of inhibitors against Envelope glycoprotein of Chikungunya Virus: a drug repositioning approach Research Papers in Peer Reviewed Journals Bioinformation 15 2019 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614119/pdf/97320630015439.pdf doi: 10.6026/97320630015439
Expression, purification and functional characterization of recombinant hypervariable region (HVR) of Chikungunya virus nsP3 protein Research Papers in Peer Reviewed Journals 3 Biotech. 9(6) 2019 https://link.springer.com/content/pdf/10.1007/s13205-019-1759-8.pdf doi: 10.1007/s13205-019-1759-8
Biotin-tagged proteins: Reagents for efficient ELISA-based serodiagnosis and phage display-based affinity selection Research Papers in Peer Reviewed Journals PLosOne 13(1) 2018 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191315 https://doi.org/10.1371/journal.pone.0191315
Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress Research Papers in Peer Reviewed Journals Scientific Reports 2045-2322 7(1) 2017 https://www.nature.com/articles/s41598-017-06003-7
Identification of potential molecular associations between chikungunya virus non-structural protein and human host proteins Research Papers in Peer Reviewed Journals Acta Virol. 61(1) 2017 https://www.elis.sk/download_file.php?product_id=5075&session_id=gh572hn30npn4f5oa0e6rimlu7 doi: 10.4149/av_2017_01_39
Host interactions of Chandipura virus matrix protein Research Papers in Peer Reviewed Journals Acta Trop 149 2015 https://pdf.sciencedirectassets.com/271036/1-s2.0-S0001706X15X00076/1-s2.0-S0001706X15001242/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEHEaCXVzLWVhc3QtMSJIMEYCIQCHarWSt0uRXSGgI4zkbv8atBnl651Yf4xfOjEh%2FLcwbgIhAMpJPQLrJFiK75g9WyRAzoXB11S6%2BZbptf%2BYxVwZS1R4KrsFCOr%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQBRoMMDU5MDAzNTQ2ODY1IgxuLt%2BCFSEU9GHSIF0qjwX4ntRqwByjqdfDqLJBVNZ0r0IiZv3a4cOZ7OSYuQjXPPl%2BhL4QiEJNNvTaTFYdk%2F8aY3gTce5kdPfY7xBPOlafBSJP258K4pDnHxj%2FkLggvVqD%2BBPAUz8BLG92%2B3Agpp%2FWXuy8NTect1XsSeRBOo95J1BkC9vk4LMpSe3tt7Ufo16VDD18vC73Yk52di9sFZJRvcwxRHcTKeTCOAdh%2FRQMveSZNzAax%2FvQBeA6LkYegsdSvxOP09ws0qta%2F%2BmYencjyzOL7c4ir6qzGkCKSb%2BXapgg%2Bq4FzZ8UBBobwSTei06vQK36Up9r7%2Fu0h8a1mrcrhoBGPT6OO2rjp8QAan2PQ6DZGYmuaeA%2Bfa8F1YgPuRgzhk2MRx0QYH%2BNVDWeDiEJ2HeH6IvYzyRXw7ecItCgMLWotKusOW%2FUNfmvcVHLrrmRDkI5uCn2UKg%2BHbeibnKPIwjZfS3io3Va9LyCGlx6DjH4Of%2BMFxKRhPNxaxAnOpd1l4wu9lSuNlsNM0fAPf4TFcCizoCB%2BtDs%2F5eJ6Xt%2FMDxLV0EO92MX%2BZFCDVtvIcAiV%2FmbZ4I8YtMn1uDwUZtKucQDylsd3gYTmMnggSob8LXZWETAg1wvQ3KdRs7nLAggIUcKtNZW00j33El8fE8AEoO5QOqQ6jO2OXKtRyJAzOpSeyl2%2FlH8uHxgxK0Kg%2FIvVPs%2FtXj%2FVJUQaFiTKJvsaWONLsdqIs6nEE5D%2FnYfU%2FFCbITNSBE3hvVxXcghTiFDAxxB3dXJv%2Bok9L7hloYZQBS0jUoLidIaCQ3nu7BZzZMbzRAcTLI9tdnAmSFO0ugfK9KEI78sihTGyNEsvOK2d9pqJVn%2Fg9%2FR6P10H2eV1G9HSZ0dp5qR46UI0O5vMKmu1rIGOrABflfem3Z3IVq6dOu%2BLlgOslac1Qnc26yWn%2FqV8jpfOkUdWqTufOi9mhFZzMa0nZVR9RYYwh9sw3%2FUgx548X7YHB1KbdX2xKrefQqAjwgBgtTB1yx2Ywv9c0NwVoWJdRT1r%2FkCCmAzAj%2BPyj0bYoXDOcXRb9gQlLxJ9dJW8r8J4wWkjouykN9wzoRZWw0G73Q5KwG6ZHsvg%2Btf2BluQ1jXC2izeF1Ens9OsIUQHzGOqOs%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240528T090821Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYREZQJEW6%2F20240528%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=51dcde43f9073efeb0f6c5e0fe8a6c7328713dfd6353711276521fc62ae30257&hash=53450c5ad66f3811bddd972f2196c90f329e8ec40e9324ca84b151efa6c1d35f&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0001706X15001242&tid=spdf-e64af6cc-b57c-45e9-b711-d208f726912d&sid=22c7cc244e1415471119312918c106702c7cgxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0d095e5903035e5656&rr=88ad1981df07339c&cc=in DOI: 10.1016/j.actatropica.2015.04.027
Host-pathogen interactome analysis of Chikungunya virus envelope proteins E1 and E2 Research Papers in Peer Reviewed Journals Virus Genes 50(2) 2015 https://link.springer.com/article/10.1007/s11262-014-1161-x DOI: 10.1007/s11262-014-1161-x
Rapid Restriction Enzyme-Free Cloning of PCR Products: A High-Throughput Method Applicable for Library Construction Research Papers in Peer Reviewed Journals PLosOne 9(10) 2014 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216109/pdf/pone.0111538.pdf doi: 10.1371/journal.pone.0111538
Network mapping among the functional domains of Chikungunya virus nonstructural proteins Research Papers in Peer Reviewed Journals Proteins: Structure, Function, and Bioinformatics 82(10) 2014 https://onlinelibrary.wiley.com/doi/epdf/10.1002/prot.24602 doi: 10.1002/prot.24602
A new microarray platform for whole-genome expression profiling of Mycobacterium tuberculosis Research Papers in Peer Reviewed Journals J Microbiol Methods 97 2013 https://pubmed.ncbi.nlm.nih.gov/24365110/ doi: 10.1016/j.mimet.2013.12.009
A Novel Helper Phage Enabling Construction of Genome-Scale ORF-Enriched Phage Display Libraries Research Papers in Peer Reviewed Journals PLosOne 8(9) doi: 10.1371/journal.pone.0075212
Elucidating the interacting domains of chandipura virus nucleocapsid protein Research Papers in Peer Reviewed Journals Adv Virol 2013 2013 doi: 10.1155/2013/594319
A robust and efficient method for the isolation of DNA-free, pure and intact RNA from Mycobacterium tuberculosis Research Papers in Peer Reviewed Journals J Microbiol Methods 93(3) 2013 https://www.sciencedirect.com/science/article/pii/S0167701213001139?via%3Dihub doi: 10.1016/j.mimet.2013.03.018
Mapping interactions of Chikungunya virus nonstructural proteins Research Papers in Peer Reviewed Journals Virus Res. 169(1) 2012 https://www.sciencedirect.com/science/article/pii/S0168170212003024?via%3Dihub DOI: 10.1016/j.virusres.2012.08.006
Intraviral protein interactions of Chandipura virus Research Papers in Peer Reviewed Journals Arch Virol. 157(10) 2012 https://link.springer.com/article/10.1007/s00705-012-1389-5 DOI: 10.1007/s00705-012-1389-5
Directed evolution of an anti-human red blood cell antibody Research Papers in Peer Reviewed Journals mAbs 1(3) doi: 10.4161/mabs.1.3.8231
Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis Research Papers in Peer Reviewed Journals FEMS Microbiol 290(1) 2008 https://pubmed.ncbi.nlm.nih.gov/19016878/ DOI: 10.1111/j.1574-6968.2008.01400.x
Bifunctional recombinant fusion proteins for rapid detection of antibodies to both HIV-1 and HIV-2 in whole blood Research Papers in Peer Reviewed Journals BMC Biotechnology 06 2006 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599719/pdf/1472-6750-6-39.pdf doi: 10.1186/1472-6750-6-39
Serogroup-reactive and type-specific detection of bluetongue virus antibodies using chicken scFvs in inhibition ELISAs Research Papers in Peer Reviewed Journals J Virol Methods 129(1) 2005 https://www.sciencedirect.com/science/article/pii/S0166093405001588?via%3Dihub DOI: 10.1016/j.jviromet.2005.04.015
Expression and purification of recombinant antigens of Mycobacterium tuberculosis for application in serodiagnosis Research Papers in Peer Reviewed Journals Protein Expression Purification 44 2005 doi: 10.1016/j.pep.2005.04.014.
Expression and purification of recombinant 38-kDa and Mtb81 antigens of Mycobacterium tuberculosis for application in serodiagnosis Research Papers in Peer Reviewed Journals Protein Expression Purification 40 2004 https://www.sciencedirect.com/science/article/pii/S1046592804003535?via%3Dihub doi: 10.1016/j.pep.2004.10.016
Whole-Blood Agglutination Assay for On-Site Detection of Human-Immunodeficiency Virus Infection Research Papers in Peer Reviewed Journals J. Clin. Microbiol. 41(7) DOI: 10.1128/JCM.41.7.2814-2821.2003
Expression, purification and characterization of an anti-RBCFab-p24 fusion protein for haemagglutination based rapid detection of antibodies to HIV in whole blood Research Papers in Peer Reviewed Journals Protein Expression Purification 26 doi: 10.1016/s1046-5928(02)00532-6
Recombinant fusion proteins for haemagglutination-based rapid detection of antibodies to HIV in whole blood Research Papers in Peer Reviewed Journals J Immunol Methods 256 doi: 10.1016/s0022-1759(01)00435-5
Mapping of HIV-1 Gag epitopes recognized by polyclonal antibodies using gene-fragment phage display system Research Papers in Peer Reviewed Journals Prep Biochem Biotechnol 31 doi: 10.1081/PB-100103383
Gag-derived proteins of HIV-1 isolates from Indian patients: cloning, expression, and purification of p17 of B- and C-subtypes Research Papers in Peer Reviewed Journals Protein Expr Purif 21 doi: 10.1006/prep.2001.1389
Gag-derived proteins of HIV-1 isolates from Indian patients: cloning, expression, and purification of p24 of B- and C-subtypes Research Papers in Peer Reviewed Journals Protein Expr Purif 19 doi: 10.1006/prep.2000.1266
Simplified gene-fragment phage display system for epitope mapping. Research Papers in Peer Reviewed Journals Biotechniques 27 doi: 10.2144/99272st04
High Density Functional Display Of Proteins On Bacteriophage Lambda Research Papers in Peer Reviewed Journals J. Mol. Biol. 334 2003 doi: 10.1016/j.jmb.2003.09.033
HIV Diagnostics: Saving Lives, Slowing The Pandemic. Research Papers in Peer Reviewed Journals Proc. Indian Natl. Acad. Sci. 29 2006
Small scale expression, solubilization, and characterization of Chikungunya virus structural proteins Research Papers in Peer Reviewed Journals Asian Journal of Pharmaceutical and Clinical Research 2455-3891 7(5) 2014
Non-Journal Publications
Title of Publication Type of Publication Publisher Role ISBN Year Link to Publication Level
Recent Advances in Chikungunya Virus Therapeutics: An Overview Chapters in Books Nova Science Publishers, Inc. (USA) Author 978-1-53619-978-9 2021 International
Phage Display: A molecular fashion show Chapters in Books American Society of Microbiology (ASM) Author 1-55581-307-0 2006 International
Research Projects
Project Title Project Type Year Of Sanction Outcome/Output Duration
Understanding the Role of Ser/Thr Protein Kinases in the regulation of Toxin-Antitoxin Loci in Mycobacterium tuberculosis (with Dr. Vandana Malhotra, SVC, DU) Major 2021 15-07-2021 To 14-07-2024 (2 years, 11 months, 29 days)
Therapeutic Antibodies for COVID-19 (with Gennova Biopharmaceuticals Ltd. as collaborator) Major 2020 25-11-2020 To 24-11-2024 (3 years, 11 months, 30 days)
Centre of Excellence entitled “Antibody Technology: Research for therapeutic and diagnostic application Major 2017 30-12-2017 To 29-12-2023 (5 years, 11 months, 29 days)
DBT-supported Genomic Facility at University of Delhi South Campus Major 2018 23-02-2018 To 21-02-2022 (3 years, 11 months, 29 days)
Identification of mycobacterial proteins and novel antigenic epitopes having immunodiagnostic potential and development of reagents for point of care test for tuberculosis (with NITRD as collaborator) Major 2018 06-02-2018 To 05-08-2022 (4 years, 5 months, 30 days)
Understanding the role of Rv1955-Rv1956 Toxin-antitoxin (TA) locus of M. tuberculosis in pathogen biology Major 2016 21-07-2016 To 20-07-2019 (2 years, 11 months, 29 days)
Development of reagents for simple immunochemical tests for the detection of Chikungunya infection (with Dr. Sanjay Gupta, JIIT, NOIDA and Dr Shymelendu Chatterjee, ICMR Virus Unit Kolkata) Major 2014 20-03-2014 To 19-09-2017 (3 years, 5 months, 30 days)
Identification and characterization of Promoters of Toxin Antitoxin loci in Mycobacterium tuberculosis Major 2014 01-10-2014 To 31-03-2019 (4 years, 5 months, 30 days)
DNA Sequencing facility at UDSC (Phase V) Major 2014 13-06-2014 To 21-09-2017 (3 years, 3 months, 8 days)
Development and production of a therapeutic monoclonal antibody against eNAMPT, a novel inflammatory target (with Gennova Biopharmaceuticals Ltd) Major 2011 01-03-2011 To 31-05-2016 (5 years, 2 months, 30 days)
A system for enhanced production of recombinant proteins in Mycobacteria Major 2011 01-03-2011 To 31-08-2014 (3 years, 5 months, 30 days)
Antitoxin-Toxin loci of Mycobacterium tuberculosis: Identification and Biochemical Characterisation Major 2010 09-03-2010 To 31-03-2014 (4 years, 22 days)
High performing lateral-flow type assay concepts for cardiac and infectious disease testing (ICGEB, New Delhi and University of Turku, Finland Major 2010 02-03-2010 To 31-07-2013 (3 years, 4 months, 29 days)
DNA sequencing facility at UDSC (Phase (IV) Major 2005 21-11-2005 To 29-09-2010 (4 years, 10 months, 8 days)
“Doctor’s office diagnostic instrument for detection of M. tuberculosis under “in the field” conditions adapted for use by unskilled personnel” Indo (DBT)-Sweden collaboration Major 2009 09-09-2009 To 08-09-2012 (2 years, 11 months, 30 days)
“Development of reagents for simple and rapid immunochemical test for culture confirmation of Mycobacterium tuberculosis complex” & Multi Centre Evaluation of TBConfirm test (A rapid Immuno-chromatography test) for culture confirmation of M. tuberculosis Major 2006 27-09-2006 To 22-03-2013 (6 years, 5 months, 23 days)
Genome wide cloning, expression and purification of toxin and antitoxin proteins of Mycobacterium tuberculosis and development of reagents for studying the physiological role of these proteins Major 2007 22-02-2007 To 20-08-2010 (3 years, 5 months, 29 days)
Antitoxin-Toxin loci of Mycobacterium tuberculosis: Identification and Biochemical Characterization Major 2006 03-05-2006 To 08-03-2010 (3 years, 10 months, 5 days)
Patents
Patent Title Patent Number Patent Level Patent Status
An antibody fragment library, and uses thereof 3717682 International Published
An antibody fragment library, and uses thereof 11725306 International Published
An antibody fragment library, and uses thereof 320566 National Published
An antibody fragment library, and uses thereof 106694 National Published
A process for immobilizing polypeptides 201711040047 National Published
A process for immobilizing polypeptides 092742 National Published
Process for purifying emulsion PCR mixture, and implementations thereof 201811038157 National Published
A process of producing ORF-enriched phage display library and uses thereof 418973 National Published
Improved process for expression, purification and enhanced recovery of mycobacterial recombinant proteins 263766 National Published
Lambda phage display system and The Process 7410801 International Published
A process of obtaining recombinant lambdoid bacteriophage and the resultant novel phage display system 096969 National Published
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