Title Prof. First Name Surajit Last Name Sarkar
Designation Professor
Department Department of Genetics SDC
Email sarkar@south.du.ac.in
Webpage
Phone.no 9968350077
Employement Info
Employee Type Nature Of Employment
Teaching Permanent
Educational Qualifications
Degree/Certification Name Institution Year of Completion
Ph.D. - Ph.D Banaras Hindu University 2007
PG Banaras Hindu University 2001
UG Banaras Hindu University 1999
Qualifications
Examination Name Conducting Body Date of Passing
NET Council of Scientific and Industrial Research (CSIR), New Delhi 30-12-2001
Fellowship Details
Name Of Fellowship Awarding Body Fellowship Level
BOYSCAST Fellowship Department of Science and Technology (DST), Government of India National
Research Supervision Overview
PhD Scholars Supervised PhD Degrees Awarded Theses Submitted
5 7 0
M.Phil Scholars Supervised M.Phil Degrees Awarded M.Phil Theses Submitted
0 2 0
Research Publications
Title of Article Type of Publication Name of Journal ISSN Journal Volume Year Link to Article DOI (Digital Object Identifier)
Myc functions downstream of InR and their concurrent upregulation additively restricts pathogenesis of human poly(Q) disorders in Drosophila disease models Research Papers in Scopus Listed Journals The International Journal of Biochemistry & Cell Biology 1357-2725 177 2024 https://www.sciencedirect.com/science/article/pii/S1357272524001833?via%3Dihub https://doi.org/10.1016/j.biocel.2024.106690
Polyglutamine disorders: Pathogenesis and potential drug interventions. Research Papers in Scopus Listed Journals Life Sciences 1879-0631 344 2024 https://www.sciencedirect.com/science/article/pii/S0024320524001516?via%3Dihub https://doi.org/10.1016/j.lfs.2024.122562
Targeted upregulation of dMyc restricts JNK-mediated degeneration of dopaminergic neurons in the paraquat-induced Parkinson's disease model of Drosophila. Research Papers in Scopus Listed Journals Neuroscience Research 1872-8111 Ahead of Print https://www.sciencedirect.com/science/article/pii/S0168010223001955?via%3Dihub https://doi.org/10.1016/j.neures.2023.10.005
Reinstated activity of human tau-induced enhanced insulin signaling restricts disease pathogenesis by regulating the functioning of kinases/phosphatases and tau hyperphosphorylation in Drosophila. Research Papers in Scopus Listed Journals Molecular Neurobiology 1559-1182 doi: 10.1007/s12035-023-03599-y https://link.springer.com/article/10.1007/s12035-023-03599-y https://doi.org/10.1007/s12035-023-03599-y
Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models. Research Papers in Scopus Listed Journals Nutritional Neuroscience 1476-8305 Ahead of Print https://www.tandfonline.com/doi/full/10.1080/1028415X.2023.2253028?scroll=top&needAccess=true https://doi.org/10.1080/1028415X.2023.2253028
Glipizide ameliorates human poly(Q) mediated neurotoxicity by upregulating insulin signalling in Drosophila disease models. Research Papers in Scopus Listed Journals Biochemical and Biophysical Research Communications 1090-2104 645 https://www.sciencedirect.com/science/article/pii/S0006291X23000451 https://doi.org/10.1016/j.bbrc.2023.01.022
Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in Drosophila Research Papers in Scopus Listed Journals Molecular Biology Reports 1573-4978 49 https://doi.org/10.1007/s11033-022-07498-8
The past and present of Drosophila models of traumatic brain injury Research Papers in Scopus Listed Journals Journal of Neuroscience Methods 0165-0270 371 https://doi.org/10.1016/j.jneumeth.2022.109533
Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila Research Papers in Scopus Listed Journals Biofactors 1872-8081 47 https://doi.org/10.1002/biof.1721
Applications of electron microscopy in Drosophila neurobiology research Research Papers in Scopus Listed Journals Indian Journal of Biochemistry and Biophysics 0975-0959 58 10.56042/ijbb.v58i4.51472
Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation Research Papers in Scopus Listed Journals Neurochemistry International 0197-0186 146 https://doi.org/10.1016/j.neuint.2021.105040
The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila Research Papers in Scopus Listed Journals Life Sciences 0024-3205 275 https://doi.org/10.1016/j.lfs.2021.119358
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Research Papers in Scopus Listed Journals Autophagy 1554-8635 17 https://doi.org/10.1080/15548627.2020.1797280
Age dependent trans-cellular propagation of human tau aggregates in Drosophila disease models Research Papers in Scopus Listed Journals Brain Reserach 0006-8993 1751 https://doi.org/10.1016/j.brainres.2020.147207
Reduced expression of dMyc mitigates TauV337M mediated neurotoxicity by preventing the Tau hyperphosphorylation and inducing autophagy in Drosophila Research Papers in Scopus Listed Journals Neuroscience Letters 0304-3940 715 https://doi.org/10.1016/j.neulet.2019.134622
Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila Research Papers in Scopus Listed Journals Molecular and Cellular Neuroscience 1044-7431 100 https://doi.org/10.1016/j.mcn.2019.103398
Neurofibrillary tangles mediated human neuronal tauopathies: insights from fly models Research Papers in Scopus Listed Journals Journal of Genetics 0973-7731 97 https://doi.org/10.1007/s12041-018-0962-4
Tissue-specific upregulation of Drosophila insulin receptor (InR) mitigates poly(Q)-mediated neurotoxicity by restoration of cellular transcription machinery Research Papers in Scopus Listed Journals Molecular Neurobiology 1559-1182 56 https://doi.org/10.1007/s12035-018-1160-3
Drosophila globin1 is required for maintenance of the integrity of F-actin based cytoskeleton during development Research Papers in Scopus Listed Journals Experimental Cell Research 0014-4827 366 https://doi.org/10.1016/j.yexcr.2018.03.005
Targeted downregulation of dMyc restricts neurofibrillary tangles mediated pathogenesis of human neuronal tauopathies in Drosophila Research Papers in Scopus Listed Journals Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 0925-4439 1863 https://doi.org/10.1016/j.bbadis.2017.05.017
Targeted downregulation of dMyc suppresses pathogenesis of human neuronal tauopathies in Drosophila by limiting heterochromatin relaxation and tau hyperphosphorylation Research Papers in Scopus Listed Journals Molecular Neurobiology 1559-1182 54 https://doi.org/10.1007/s12035-016-9858-6
Transactivation domain of human c-Myc is essential to alleviate poly(Q)-mediated neurotoxicity in Drosophila disease models Research Papers in Scopus Listed Journals Journal of Molecular Neuroscience 1559-1166 62 https://doi.org/10.1007/s12031-017-0910-4
Drosophila glob1 is required for the maintenance of cytoskeletal integrity during oogenesis Research Papers in Scopus Listed Journals Developmental Dynamics 1097-0177 245 https://doi.org/10.1002/dvdy.24436
Drosophila glob1 expresses dynamically and is required for development and oxidative stress response Research Papers in Scopus Listed Journals Genesis 1526-968X 53 https://doi.org/10.1002/dvg.22902
Drosophila Myc, a novel modifier suppresses the poly(Q) toxicity by modulating the level of CREB binding protein and histone acetylation Research Papers in Scopus Listed Journals Neurobiology of Disease 0969-9961 63 https://doi.org/10.1016/j.nbd.2013.11.015
In vivo toxicity assessment of antimicrobial peptides (AMPs LR14) derived from Lactobacillus plantarum strain LR/14 in Drosophila melanogaster Research Papers in Scopus Listed Journals Probiotics and Antimicrobial Proteins 1867-1306 6 https://doi.org/10.1007/s12602-013-9154-y
Heat shock proteins: molecules with assorted functions Research Papers in Scopus Listed Journals Frontiers in Biology 1673-3622 6 https://doi.org/10.1007/s11515-011-1080-3
Hsp60C is required in follicle as well as germline cells during oogenesis in Drosophila melanogaster Research Papers in Scopus Listed Journals Developmental Dynamics 1097-0177 237 https://doi.org/10.1002/dvdy.21524
The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility Research Papers in Scopus Listed Journals Journal of Genetics 0973-7731 84 10.1007/BF02715797
Non-Journal Publications
Title of Publication Type of Publication Publisher Role ISBN Year Link to Publication Level
Drosophila melanogaster: An immaculate model for glial research Chapters in Books Springer Nature Co-Author 978-981-16-8312-1 International
A rapid assessment of neuromuscular performance of Drosophila larvae Chapters in Books Indian Academy of Sciences Co-Author 978-81-13-950664-2-1 International
Aging: reading, reasoning and resolving using Drosophila as a model system Chapters in Books Springer Nature Co-Author 978-981-13-3585-3 International
Tau, tangles and tauopathies: Insights from Drosophila disease models Chapters in Books Springer Nature Co-Author 978-981-13-2217-4 International
Drosophila melanogaster: A prime experimental model system for aging studies Chapters in Books Springer Nature Co-Author 978-981-10-2154-1 International
Chaperonins: In life and death Chapters in Books Research Signpost Co-Author 81-308-0109-4 National
Honors and Awards
Name of the Award Awarding Body Award Category Level Award Date
Excellence Award for In-Service Teachers of University of Delhi University of Delhi Academic State/University Level 01-05-2019
Innovative Young Biotechnologist Award Department of Biotechnology (DBT), Government of India Research National 13-12-2017
Young Scientist Award Department of Science and Technology (DST), Government of India Research National 19-03-2009
DST-BOYSCAST Fellowship Department of Science and Technology (DST), Government of India Research National 03-06-2010
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