Title Dr. First Name Hemlata Last Name Agnihotri
Designation Assistant Professor
Department Department of BioPhysics SDC
Email hemlata.lifescience@gmail.com
Webpage
Phone.no 24117191
Employement Info
Employee Type Nature Of Employment
Teaching Permanent
Educational Qualifications
Degree/Certification Name Institution Year of Completion
Ph.D. - Biological Sciences CSIR-Central Drug Research Institute, Lucknow 2016
PG CSJM University, Kanpur 2007
UG CSJM University, Kanpur 2005
Qualifications
Examination Name Conducting Body Date of Passing
NET CSIR-UGC 17-06-2007
Fellowship Details
Name Of Fellowship Awarding Body Fellowship Level
ICMR-Senior Research Fellowship Indian Council of Medical Research National
CSIR- Senior Research Fellowship Council of Scientific and Industrial Research National
DST-SERB National Post Doctoral Fellow Department of Science & Technology and Science & Engineering Research Board National
Administrative Experience (Within Institution)
Designation Duration
Resident tutor Presently Working since 21-10-2022 (2 years, 8 months, 10 days)
Member, Departmental Purchase Committee Presently Working since 15-09-2022 (2 years, 9 months, 16 days)
Courses/Subjects Taught
Teaching Activity Type Course Title Semester Total Assigned Classes Number of Classes Taught Duration
Lecture Mathematics and Statistics for Life Sciences 1 1 10 07-12-2022 To 15-03-2023 (3 months, 8 days)
Lecture Introductory Biology BPCC101 1 2 20 06-12-2022 To 14-03-2023 (3 months, 8 days)
Lecture Introductory Physics and Chemistry 1 2 26 05-12-2022 To 13-03-2023 (3 months, 8 days)
Practical Practicals-I (Based on BPCC104 and BPCC105) 1 3 27 06-12-2022 To 07-03-2023 (3 months, 1 days)
Tutorial Based on course code BPCC101, 102, 103 1 2 14 05-12-2022 To 13-03-2023 (3 months, 8 days)
Lecture BPCC103: Mathematics and Statistics for Life Sciences 1 13 13 01-09-2023 To 28-12-2023 (3 months, 27 days)
Lecture BPCC102: Introductory Physics & Chemistry 1 36 36 01-09-2023 To 28-12-2023 (3 months, 27 days)
Lecture BPCC101: Introductory Biology 1 32 32 01-09-2023 To 28-12-2023 (3 months, 27 days)
Practical BPCC303: Practicals-III (Based on BPCC301, BPCC302, MBCC303)) 3 240 240 01-09-2023 To 28-12-2023 (3 months, 27 days)
Lecture BPCC302: Physiological Biophysics 3 34 34 01-09-2023 To 28-12-2023 (3 months, 27 days)
Lecture BPCC301: Cellular Biophysics and Bioenergetics 3 47 47 01-09-2023 To 28-12-2023 (3 months, 27 days)
Practical BPCC203: Practicals - II 2 240 240 17-04-2023 To 03-08-2023 (3 months, 17 days)
Lecture BPCC201: Molecular Biophysics 2 22 22 17-04-2023 To 04-08-2023 (3 months, 18 days)
Lecture BPCC103: Mathematics and Statistics for Life Sciences 1 13 13 05-12-2022 To 23-01-2023 (1 months, 18 days)
Lecture BPCC102: Introductory Physics & Chemistry 1 36 36 05-12-2022 To 23-01-2023 (1 months, 18 days)
Lecture BPCC101: Introductory Biology 1 32 32 05-12-2022 To 23-03-2023 (3 months, 18 days)
Practical BPCC402: Dissertation/ Project 4 480 480 05-01-2023 To 29-05-2023 (4 months, 24 days)
Lecture BPCC401: Membrane Biophysics and Neuro-Biophysics 4 34 34 05-01-2023 To 29-05-2023 (4 months, 24 days)
Lecture BPCC302: Physiological Biophysics 3 34 34 26-08-2022 To 12-12-2022 (3 months, 16 days)
Practical BPCC303: Practicals-III (Based on BPCC301, BPCC302, MBCC303)) 3 240 240 26-08-2022 To 12-12-2022 (3 months, 16 days)
Lecture BPCC301: Cellular Biophysics and Bioenergetics 3 47 47 26-08-2022 To 12-12-2022 (3 months, 16 days)
Research Supervision Overview
PhD Scholars Supervised PhD Degrees Awarded Theses Submitted
1 0 0
M.Phil Scholars Supervised M.Phil Degrees Awarded M.Phil Theses Submitted
1 2 0
Research Publications
Title of Article Type of Publication Name of Journal ISSN Journal Volume Year Link to Article DOI (Digital Object Identifier)
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody. (JOINT FIRST AUTHOR) Research Papers in Peer Reviewed Journals Nature communications 13(1):4634 https://www.nature.com/articles/s41467-022-32386-x doi: 10.1038/s41467-022-32386-x
Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR. Research Papers in Peer Reviewed Journals Nature communications 12(1):7158. https://www.nature.com/articles/s41467-021-27482-3 doi: 10.1038/s41467-021-27482-3. PMID: 34887409; PMCID: PMC8660791.
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Research Papers in Peer Reviewed Journals Molecular Cell 81(22): https://www.sciencedirect.com/science/article/pii/S1097276521007413?via%3Dihub doi: 10.1016/j.molcel.2021.09.007. PMID: 34582793; PMCID: PMC7612807.
Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling Research Papers in Peer Reviewed Journals Science Advances https://www.science.org/doi/10.1126/sciadv.abb8368 DOI: 10.1126/sciadv.abb8368
Key phosphorylation sites in GPCRs orchestrate the contribution of beta-Arrestin 1 in ERK1/2 activation. (JOINT FIRST AUTHOR) Research Papers in Peer Reviewed Journals EMBO Reports https://www.embopress.org/doi/full/10.15252/embr.201949886 https://doi.org/10.15252/embr.201949886
Genetically encoded intrabody sensors report the interaction and trafficking of beta-arrestin 1 upon activation of G-protein-coupled receptors. The Journal of Biological Chemistry. 295, 10153-10167. (Equal contribution/ Joint first author) Research Papers in Peer Reviewed Journals The Journal of Biological Chemistry https://www.jbc.org/action/showPdf?pii=S0021-9258%2817%2950129-5 DOI:https://doi.org/10.1074/jbc.RA120.013470
An intrabody sensor to monitor conformational activation of β-arrestins. Methods Cell Biol. 2022;169:267-278. doi: 10.1016/bs.mcb.2021.12.023. Research Papers in Peer Reviewed Journals Methods Cell Biol https://www.sciencedirect.com/science/article/pii/S0091679X2100128X?via%3Dihub doi.org/10.1016/bs.mcb.2021.12.023
Lee, Y., Warne, T., Nehme, R., Pandey, S., Dwivedi-Agnihotri, H., Chaturvedi, M., Edwards, P. C., Garcia- Nafria, J., Leslie, A. G. W., Shukla, A. K., and Tate, C. G. (2020) Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor. Nature. 583, 862-866 Research Papers in Peer Reviewed Journals Nature. https://www.nature.com/articles/s41586-020-2419-1
GPCR Signaling: The Interplay of Galphai and beta- arrestin. Current Biology 28, R324-R327 . Research Papers in Peer Reviewed Journals Current Biology https://www.cell.com/current-biology/pdf/S0960-9822(18)30212-4.pdf
Crystal Structure of beta-Arrestin 2 in Complex with CXCR7 Phosphopeptide. Research Papers in Peer Reviewed Journals Structure https://www.cell.com/structure/home doi: 10.1016/j.str.2020.06.002.
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system. Nat Commun. 2023 Aug 9;14(1):4808. doi: 10.1038/s41467-023-40482-9. PMID: 37558722; PMCID: PMC10412580. Research Papers in Peer Reviewed Journals Nature Communications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412580/?report=reader doi: 10.1038/s41467-023-40482-9.
Biased ligands at opioid receptors: Current status and future directions. Sci Signal. 2021 Apr 6;14(677):eaav0320. doi: 10.1126/scisignal.aav0320. Research Papers in Peer Reviewed Journals Science Signaling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611221/ doi: 10.1126/scisignal.aav0320.

Purification of native CCL7 and its functional interaction with selected chemokine receptors. Protein Expr Purif. 2020 Jul;171:105617. Research Papers in Peer Reviewed Journals Protein Expression and Purification https://www.sciencedirect.com/science/article/pii/S1046592819306485?via%3Dihub doi: 10.1016/j.pep.2020.105617.
Structure and function of β-arrestins, their emerging role in breast cancer, and potential opportunities for therapeutic manipulation. Adv Cancer Res. 2020;145:139-156. Research Papers in Peer Reviewed Journals Advances in Cancer Research https://www.sciencedirect.com/science/article/pii/S0065230X20300014?via%3Dihub doi: 10.1016/bs.acr.2020.01.001.
Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms. Cell Rep. 2019 Sep 24;28(13):3287-3299.e6. Research Papers in Peer Reviewed Journals Cell Reports doi: 10.1016/j.celrep.2019.08.053.
Research Projects
Project Title Project Type Year Of Sanction Outcome/Output Duration
Targeting β-arrestin dependent GPCR signaling with highly specific molecular recognition modules as a therapeutic approach in breast cancer. Major 2019 01-09-2019 To 31-08-2022 (2 years, 11 months, 30 days)
DST-SERB NPDF Minor 2017 01-04-2017 To 31-03-2019 (1 years, 11 months, 30 days)
In silico and molecular investigation of super-conserved receptor expressed in the brain, SREB3 (GPR173): A putative therapeutic target for brain disorders Minor 2023 Ongoing since 31-08-2023 (1 years, 10 months)
Elucidating the functional insights of super-conserved receptor expressed in the brain, SREB3 (GPR173) Major 2024 Project has just started. Ongoing since 11-03-2024 (1 years, 3 months, 20 days)
Professional Development Programmes
Programme Title Sponsoring Institution Organizing Institution Role Type of Programme
Two - week Interdisciplinary Refresher Course in “ADVANCED RESEARCH METHODOLOGY” Teaching Learning Centre, Ramanujan College, University of Delhi Attendee Refresher Program
4-Week Faculty Induction/Orientation Programme for “Faculty in Universities/Colleges/Institutes of Higher Education” Teaching Learning Centre, Ramanujan College, University of Delhi Attendee Faculty Development Programmes
Patents
Patent Title Patent Number Patent Level Patent Status
Novel combination Kit for Treatment of Malaria 440383 National Published and Awarded on 25-07-2023
Talk Poster Presented
Name of the Activity Role Date of Activity
Mini Symposium on GPCR signaling and regulation, 2023 Organized at IIT Kanpur Speaker 01-02-2023
The speaker shared her experiences and journey of research on Indian Ground with the audience and patiently answered their questions. Speaker 02-09-2023
Experience Sharing by Fellowship Recipients. Speaker 27-04-2024
* This site is designed and developed by Samarth eGov and the content is provided by the individual. For further details, please contact the individual / university.
© Samarth eGov Suite - 2025