| Title | Dr. | First Name | Garima | Last Name | Khare |
|
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|---|---|---|---|---|---|---|---|
| Designation | Assistant Professor | ||||||
| Department | Department of Biochemistry SDC | ||||||
| garima1822@yahoo.co.in | |||||||
| Webpage | |||||||
| Phone.no | 24114159 | ||||||
| Employement Info | |||||||
|---|---|---|---|---|---|---|---|
| Employee Type | Nature Of Employment | ||||||
| Teaching | Permanent | ||||||
| Educational Qualifications | |||||||
|---|---|---|---|---|---|---|---|
| Degree/Certification Name | Institution | Year of Completion | |||||
| Ph.D. - Ph.D. | University of Delhi | 2012 | |||||
| PG | University of Delhi | 2006 | |||||
| UG | University of Delhi | 2004 | |||||
| Fellowship Details | |||||||
|---|---|---|---|---|---|---|---|
| Name Of Fellowship | Awarding Body | Fellowship Level | |||||
| Innovative Young Biotechnologists Award | Department of Biotechnology | National | |||||
| Senior Research Fellowship | CSIR | National | |||||
| Junior Research Fellowship | CSIR | National | |||||
| Mentorship | |||||||
|---|---|---|---|---|---|---|---|
| Student Name | Student's Affiliation | Mentoring Duration | |||||
| Simran Kaur | University of Delhi | 03-08-2016 To 01-09-2022 (6 years, 29 days) | |||||
| Research Supervision Overview | |||||||
|---|---|---|---|---|---|---|---|
| PhD Scholars Supervised | PhD Degrees Awarded | Theses Submitted | |||||
| 3 | 0 | 1 | |||||
| Research Publications | |||||||
|---|---|---|---|---|---|---|---|
| Title of Article | Type of Publication | Name of Journal | ISSN | Journal Volume | Year | Link to Article | DOI (Digital Object Identifier) |
| Inhibition of ABCG2 efflux pumps renders the Mycobacterium tuberculosis hiding in mesenchymal stem cells responsive to antibiotic treatment. | Research Papers in UGC listed Journals | Infection, Genetics and Evolution | 87 | ||||
| Unraveling the role of the transcriptional regulator VirS in low pH-induced responses of Mycobacterium tuberculosis and identification of VirS inhibitors. | Research Papers in UGC listed Journals | Journal of Biological Chemistry | 294 | ||||
| Necrosis driven triglyceride synthesis primes macrophages for inflammation during Mycobacterium tuberculosis infection. | Research Papers in UGC listed Journals | Frontiers in Immunology | 9 | ||||
| Identification of Mycobacterium tuberculosis BioA inhibitors by using structure based virtual screening | Research Papers in UGC listed Journals | Drug Design, Development and Therapy | 12 | ||||
| A combination of docking and cheminformatics approaches for the identification of inhibitors against 4’phosphopantetheinyl transferase of Mycobacterium tuberculosis | Research Papers in UGC listed Journals | RSC Advances | 8 | ||||
| Virtual Screening, pharmacophore development and structure based similarity search to identify inhibitors against IdeR, a transcription factor of Mycobacterium tuberculosis | Research Papers in UGC listed Journals | Scientific Reports | 7 | ||||
| Differential roles of iron storage proteins in maintaining the iron homeostasis in Mycobacterium tuberculosis | Research Papers in UGC listed Journals | PLoS ONE | 12 | ||||
| Novel isoniazid-amidoether derivatives: Synthesis, characterization and antimycobacterial activity evaluation | Research Papers in UGC listed Journals | Med. Chem. Commun | 6 | ||||
| Synthesis of novel 1,2,3-triazole derivatives of isoniazid and their in vitro and in vivo antimycobacterial activity evaluation | Research Papers in UGC listed Journals | European Journal of Medicinal Chemistry | 23 | ||||
| KefB inhibits phagosomal acidification but its role is unrelated to M. tuberculosis survival in host | Research Papers in UGC listed Journals | Scientific Reports | 3 | ||||
| Whole cell screening based identification of inhibitors against the intraphagosomal survival of Mycobacterium tuberculosis. | Research Papers in UGC listed Journals | Antimicrobial Agents and Chemotherapy | 57 | ||||
| Unique Residues at the 3-fold and 4-fold axis of Mycobacterial Ferritin are required in Oligomer Switching | Research Papers in UGC listed Journals | Biochemistry | 52 | ||||
| Identification of Inhibitors against Mycobacterium tuberculosis Thiamin Phosphate Synthase, an Important Target for the Development of Anti-TB Drugs | Research Papers in UGC listed Journals | PLoS ONE | 6 | ||||
| Ferritin Structure from Mycobacterium tuberculosis: Comparative Study with Homologues Identifies Extended C-terminus involved in Ferroxidase Activity | Research Papers in UGC listed Journals | PLoS ONE | 6 | ||||
| Molecular modeling studies of Fatty acyl-CoA synthetase (FadD13) from Mycobacterium tuberculosis – a potential target for the development of antitubercular drugs | Research Papers in UGC listed Journals | J. Mol. Model | 17 | ||||
| Structural Ordering of Disordered Ligand-Binding Loops of Biotin Protein Ligase into Active Conformations as a Consequence of Dehydration | Research Papers in UGC listed Journals | PLoS ONE | 5 | ||||
| Dissecting the Role of Critical Residues and Substrate Preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis | Research Papers in UGC listed Journals | PLoS ONE | 4 | ||||
| Crystal Structure of Bfr A from Mycobacterium tuberculosis: Incorporation of Selenomethionine Results in Cleavage and Demetallation of Haem | Research Papers in UGC listed Journals | PLoS ONE | 4 | ||||
| Facilitated Oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-Mediated Oligomerization | Research Papers in UGC listed Journals | Journal of Bacteriology | 191 | ||||
| A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL | Research Papers in UGC listed Journals | Nucleic Acids Research | 37 | ||||
| An inducible system for the identification of target genes for a regulator in mycobacteria. | Research Papers in Peer Reviewed Journals | American Journal of Biochemistry and Biotechnology | 4 | ||||
| Functional Studies on Multiple Thioredoxins from Mycobacterium tuberculosis | Research Papers in UGC listed Journals | Journal of Bacteriology | 190 | ||||
| Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis. | Research Papers in UGC listed Journals | Acta Crystallogr Sect F Struct Biol Cryst Commun | 64 | ||||
| Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of bacterioferritin A from Mycobacterium tuberculosis. | Research Papers in UGC listed Journals | Acta Crystallogr Sect F Struct Biol Cryst Commun | 64 | ||||
| Non-Journal Publications | |||||||
|---|---|---|---|---|---|---|---|
| Title of Publication | Type of Publication | Publisher | Role | ISBN | Year | Link to Publication | Level |
| An Insight into the Importance of Ferritins in the Physiology of Mycobacterium tuberculosis: Unique Structural and Functional Properties | Chapters in Books | Springer Nature Singapore Pte Ltd | Author | International | |||
| Challenges and Advances in TB Drug Discovery. | Chapters in Books | Springer, Singapore | Author | International | |||
| Tuberculosis: current situation, challenges and intervention strategies | Chapters in Books | Capital Publishing group, New Delhi | Author | National | |||
| Research Projects | ||||||
|---|---|---|---|---|---|---|
| Project Title | Project Type | Year Of Sanction | Outcome/Output | Duration | ||
| Maintenance and Operation of the Biosafety Facility (level 3), for Tuberculosis research, located at UDSC, New Delhi | Major | 2018 | 30-08-2018 To 28-02-2022 (3 years, 5 months, 29 days) | |||
| Drug discovery approaches for the effective control of tuberculosis – target based virtual screening and whole cell screening of medicinal plants | Major | 2018 | 18-09-2018 To 18-06-2022 (3 years, 9 months) | |||
| Targeting dormant Mycobacterium tuberculosis in Bone Marrow Mesenchymal Stem Cells by inhibiting ABCG2 efflux pumps | Major | 2019 | 31-10-2019 To 30-04-2023 (3 years, 5 months, 30 days) | |||
| Understanding the VirS mediated acid induced responses of Mycobacterium tuberculosis in maintaining the pH homeostasis in vitro and in host | Major | 2014 | 31-07-2014 To 30-07-2017 (2 years, 11 months, 29 days) | |||
| Proteomics based insights into molecular mechanisms of Mycobacterium tuberculosis persistence in human bone marrow mesenchymal stem cells as protective niche and unravel host directed therapy targets | Major | 2022 | Ongoing since 01-08-2022 (2 years, 10 months, 5 days) | |||
| Engineering antisense oligonucleotides to design novel liposome-encapsulated drugs against tuberculosis | Major | 2023 | Ongoing since 21-12-2023 (1 years, 5 months, 16 days) | |||
| Professional Development Programmes | |||||||
|---|---|---|---|---|---|---|---|
| Programme Title | Sponsoring Institution | Organizing Institution | Role | Type of Programme | |||
| Academic Research Writing | Teaching Learning Centre, Ramanujan College, University of Delhi | Attendee | Faculty Development Programmes | ||||
| Enhancing Administrative efficiency in HEIs | Teaching Learning Centre, Ramanujan College in collaboration with Janki Devi Memorial College, University of Delhi | Attendee | Faculty Development Programmes | ||||
| Skill Enhancement and Capacity Building for Teaching and Non-Teaching Staff | Kamala Nehru College, University of Delhi in collaboration with Teaching Learning Centre (under PMMMNMTT), Ramanujan College, University of Delhi | Attendee | Faculty Development Programmes | ||||
| E-learning and Developing MOOCs for Teaching Process in Higher Education | Department of Statistics and IQAC, Hindu College, University of Delhi in collaboration with PMMMNMTT Teaching Learning Centre, Ramanujan College | Attendee | Faculty Development Programmes | ||||
| Moving Towards New Normal with Effective Online Teaching | Department Of Computer Science And IQAC, Kalindi College In Collaboration With Mahatma Hansraj Faculty Development Centre, Hansraj College. | Attendee | Faculty Development Programmes | ||||
| HIGHER EDUCATION: ROAD AHEAD DEVELOPING NEXT GENERATION ACADEMIC LEADERS | Department Of Commerce And IQAC, Sri Venkateswara College In Collaboration With Teaching Learning Centre, Ramanujan College. | Attendee | Faculty Development Programmes | ||||
| TRANSFORMING LIFESTYLE THROUGH YOGA DARSHAN & ITS FUNCTIONAL MODES | Ramanujan College And Department Of Physical Education & Sports, Ramanujan College In Association With Gandhi Bhawan | Attendee | Faculty Development Programmes | ||||
| ICT ENHANCED TEACHING LEARNING AND CREATING MOOCs | Ramanujan College, University of Delhi And IQAC, Shivaji College, University of Delhi | Attendee | Faculty Development Programmes | ||||
| Orientation Programme held at CPDHE | CPDHE, DU | Attendee | Orientation Programme | ||||
| Honors and Awards | |||||||
|---|---|---|---|---|---|---|---|
| Name of the Award | Awarding Body | Award Category | Level | Award Date | |||
| Innovative Young Biotechnologists Award | Department of Biotechnology, Govt. of India | Research | National | 31-08-2014 | |||
| Talk Poster Presented | |||||||
|---|---|---|---|---|---|---|---|
| Name of the Activity | Role | Date of Activity | |||||
| Presented a talk on 'Unraveling the role of the transcriptional regulator VirS in low-pH induced responses of Mycobacterium tuberculosis' | Invited Talk | 24-11-2022 | |||||
| Unraveling the role of the transcriptional regulator VirS in low pH–induced responses of Mycobacterium tuberculosis | Invited Talk | 19-08-2022 | |||||
| Invited as a panelist for Panel Discussion on 'Research Ethics' | Invited Talk | 14-05-2022 | |||||
| Unraveling the role of the transcriptional regulator VirS in low pH–induced responses of Mycobacterium tuberculosis | Speaker | 12-02-2020 | |||||
| Engineering the natural nano cages to enhance their properties: determination of the crystal structure and generation of thermostable variants of Mycobacterium tuberculosis ferritin | Speaker | 09-01-2019 | |||||
| Targeting the phosphopantetheinylation pathway of Mycobacterium tuberculosis for the identification of new anti‐TB drugs | Oral Presentation | 30-08-2018 | |||||
| Structure based virtual screening to identify inhibitors against important drug targets of Mycobacterium tuberculosis | Invited Talk | 10-03-2018 | |||||
| Identification of inhibitors against Mycobacterium tuberculosis | Oral Presentation | 07-12-2015 | |||||
| Unraveling the role of the transcriptional regulator VirS in low pH–induced responses of Mycobacterium tuberculosis. | Speaker | 11-02-2020 | |||||
| Whole cell screening based identification of inhibitors against Mycobacterium tuberculosis. | Poster Presentation | 27-01-2014 | |||||
| Identification of inhibitors Against Mycobacterium tuberculosis Thiamin Phosphate Synthase, an important target for development of anti-TB drugs. | Poster Presentation | 01-03-2011 | |||||
| Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) belonging to a virulence associated operon of Mycobacterium tuberculosis. | Speaker | 01-01-2010 | |||||
| Presented an invited talk | Speaker | 04-05-2023 | |||||
| Delivered a talk "Taming the resilient pathogen" | Speaker | 05-07-2024 | |||||
| Presented talks on "Biorisk Management" and "Emergency Incident Response" | Speaker | 29-07-2024 | |||||