Title Dr. First Name Manish Last Name Kumar
Designation Professor
Department Department of BioPhysics SDC
Email manish@south.du.ac.in
Webpage
Phone.no 24157263
Employement Info
Employee Type Nature Of Employment
Teaching Permanent
Research Publications
Title of Article Type of Publication Name of Journal ISSN Journal Volume Year Link to Article DOI (Digital Object Identifier)
Nucleoside and non-nucleoside reverse transcriptase inhibitor drugs (NRTIs and NNRTIs) are capable of binding Chandipura virus polymerase protein (L) and inhibit virus replication. Research Papers in Web of Science Listed Journals VirusDisease 2347-3517 2024 https://link.springer.com/article/10.1007/s13337-024-00883-w 10.1007/s13337-024-00883-w

Transcriptome responses of Arabidopsis to necrotrophic fungus Alternaria brassicae reveal pathways and candidate genes associated with resistance. Research Papers in Web of Science Listed Journals Plant Molecular BIology 1573-5028 2024 https://link.springer.com/article/10.1007/s11103-024-01453-w 10.1007/s11103-024-01453-w

The potential of R. Toruloides mevalonate pathway genes in increasing isoprenoid yields in S. Cerevisiae: Evaluation of GGPPS and HMG-coa reductase Research Papers in Web of Science Listed Journals Enzyme and Microbial Technology 1879-0909 2023 https://www.sciencedirect.com/science/article/abs/pii/S0141022923001825?via%3Dihub 10.1016/j.enzmictec.2023.110374

AFRbase: A database of protein mutations responsible for antifungal resistance Research Papers in Web of Science Listed Journals Bioinformatics 2023 https://academic.oup.com/bioinformatics/article/39/11/btad677/7382209?login=false 10.1093/bioinformatics/btad677

Genomic analysis of phylogroup D Escherichia coli strains using novel de-novo reference-based guided assembly Research Papers in Web of Science Listed Journals Scientific Data 2052-4463 2023 https://www.nature.com/articles/s41597-023-02444-0 10.1038/s41597-023-02444-0

Comprehensive genomic analysis of hypocholesterolemic probiotic Enterococcus faecium LR13 reveals unique proteins involved in cholesterol-assimilation Research Papers in Web of Science Listed Journals Frontiers in Microbiology 2023 https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1082566/full 10.3389/fnut.2023.1082566

ProSeqAProDB: Prosequence assisted protein Database. Research Papers in Web of Science Listed Journals Journal of Molecular Biology 2023 https://www.sciencedirect.com/science/article/abs/pii/S0022283623000785 10.1016/j.jmb.2023.168022

β-LacFamPred: An online tool for prediction and classification of β-lactamase class, subclass, and family. Research Papers in Web of Science Listed Journals Frontiers in Microbiology 1664-302X 2023 https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1039687/full 10.3389/fmicb.2022.1039687

BacARscan: an in-silico resource to discern diversity in antibiotic resistance genes. Research Papers in Web of Science Listed Journals Biology Methods & Protocols. 2396-8923 2022 https://academic.oup.com/biomethods/article/7/1/bpac031/6854969 10.1093/biomethods/bpac031

Designing dual inhibitors against potential drug targets of Plasmodium falciparum -M17 Leucyl Aminopeptidase and Plasmepsins Research Papers in Web of Science Listed Journals Journal of Biomolecular Structure and Dynamics 2022 https://www.tandfonline.com/doi/abs/10.1080/07391102.2022.2129452 10.1080/07391102.2022.2129452

Protein expression profiling, in silico classification and pathway analysis of cariogenic bacteria Streptococcus mutans under bacitracin stress conditions. Research Papers in Web of Science Listed Journals Journal of Medical Microbiology 2022 https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001572 10.1099/jmm.0.001572

Insights into the human gut virome by sampling a population from the Indian subcontinent. Research Papers in Web of Science Listed Journals Journal of General Virology 1465-2099 2022 https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001774#tab2 10.1099/jgv.0.001774

Heterologous expression of novel SUMO proteases from Schizosaccharomyces pombe in E. coli: Catalytic domain identification and optimization of product yields. International. Research Papers in Web of Science Listed Journals Journal of Biological Macromolecules 2022 https://www.sciencedirect.com/science/article/abs/pii/S0141813022007863?via%3Dihub 10.1016/j.ijbiomac.2022.04.078

Investigating the disordered regions (MoRFs, SLiMs and LCRs) and functions of mimicry proteins/peptides in silico. PloS One Research Papers in Web of Science Listed Journals PLOS ONE 1932-6203 2022 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0265657 10.1371/journal.pone.0265657

Proteome profiling of carbapenem-resistant K. pneumoniae clinical isolate (NDM-4): Exploring the mechanism of resistance and potential drug targets Research Papers in Peer Reviewed Journals J Proteomics 1874-3919 200 10.1016/j.jprot.2019.04.003

Public health implications of plasmid-mediated quinolone and aminoglycoside resistance genes in Escherichia coli inhabiting a major anthropogenic river of India Research Papers in Web of Science Listed Journals Epidemiology & Infection 1469-4409 2022 https://www.cambridge.org/core/journals/epidemiology-and-infection/article/public-health-implications-of-plasmidmediated-quinolone-and-aminoglycoside-resistance-genes-in-escherichia-coli-inhabiting-a-major-anthropogenic-river-of-india/D92A82CC71595A9A179CC7D724FF0E50#metrics 10.1017/S095026882200053X

Proteomic Analysis of the Colistin-resistant E. coli Clinical Isolate: Explorations of the Resistome. Research Papers in Web of Science Listed Journals Protein & Peptide Letters 1875-5305 2022 https://www.eurekaselect.com/article/119104 10.2174/0929866528666211129095001

Investigating the OXA variants of ESKAPE pathogens. Research Papers in Web of Science Listed Journals Antibiotics 2079-6382 2021 https://www.mdpi.com/2079-6382/10/12/1539 10.3390/antibiotics10121539

Efficacy of signal peptide predictors in identifying signal peptides in the experimental secretome of Picrophilous torridus, a thermoacidophilic archaeon. Research Papers in Web of Science Listed Journals PLOS ONE 1932-6203 2021 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255826 10.1371/journal.pone.0255826

Rhizospheric Lactobacillus plantarum (Lactiplantibacillus plantarum) exhibit bile salt hydrolysis, hypocholestrolemic and probiotic capabilities. Research Papers in Web of Science Listed Journals Scientific Reports 2045-2322 2021 https://www.nature.com/articles/s41598-021-94776-3 10.1038/s41598-021-94776-3

Exploring the genetic mechanisms underlying amoxicillin-clavulanate resistance in waterborne Escherichia coli Research Papers in Peer Reviewed Journals Infection Genetics & Evolution 15677257, 15671348 90 10.1016/j.meegid.2021.104767

Discerning novel drug targets for treating Mycobacterium avium ss. paratuberculosis associated autoimmune disorders: an in silico approach Research Papers in Peer Reviewed Journals Briefings in Bioinformatics 1477-4054 22 10.1093/bib/bbaa195

In-silico Design of a Multivalent Epitope-Based Vaccine against Candida auris Research Papers in Peer Reviewed Journals Microbial Pathogenesis 0882-4010 155 10.1016/j.micpath.2021.104879

High Prevalence of Drug Resistance and Class 1 Integrons in Escherichia coli Isolated From River Yamuna, India A Serious Public Health Risk Research Papers in Peer Reviewed Journals Frontiers in Microbiology 1664302X 56 10.3389/fmicb.2021.621564

Exploring the genetic mechanisms underlying amoxicillin-clavulanate resistance in waterborne Escherichia coli. Research Papers in Web of Science Listed Journals Infection Genetics & Evolution 567-7257 90 2021 https://www.sciencedirect.com/science/article/abs/pii/S1567134821000642 10.1016/j.meegid.2021.104767

Comparative Proteomics of Commensal and Pathogenic Strains of Escherichia coli Research Papers in Peer Reviewed Journals Protein and Peptide Letters 1875-5305 27 10.2174/0929866527666200517104154

Identification of binding partners of CsaA - an archaeal chaperonic pro-tein of Picrophilus torridus Research Papers in Peer Reviewed Journals Protein and Peptide Letters 09298665, 18755305 28 10.2174/0929866527999201126205131

Exploring the genetic determinants underlying the differential production of an inducible chromosomal cephalosporinase - BlaB in Yersinia enterocolitica biotypes 1A, 1B, 2 and 4 Research Papers in Peer Reviewed Journals Scientific Reports 2045-2322 NA 10.1038/s41598-020- 67174-4

BacEffluxPred: A two-tier system to predict and categorize bacterial efflux mediated antibiotic resistance proteins Research Papers in Peer Reviewed Journals Scientific Reports 2045-2322 NA 10.1038/s41598-020-65981-3

Biophysical and biochemical characterization of nascent polypeptide associated complex of Picrophilus torridus and elucidation of its interacting partners Research Papers in Peer Reviewed Journals Frontiers in Microbiology 1664302X NA 10.3389/fmicb.2020.00915

mRNALoc: a novel machine-learning-based in-silico tool to predict mRNA subcellular localization Research Papers in Peer Reviewed Journals Nucleic Acids Research NA 48 10.1093/nar/gkaa385

Comparative in-silico proteomic analysis discerns potential granuloma proteins of Yersinia pseudotuberculosis Research Papers in Peer Reviewed Journals Scientific Reports 2045-2322 NA 10.1038/s41598-020-59924-1

Down-Regulation of Flagellar, Fimbriae, and Pili Proteins in Carbapenem-Resistant Klebsiella pneumoniae (NDM-4) Clinical Isolates: A Novel Linkage to Drug Resistance Research Papers in Peer Reviewed Journals Frontiers in Microbiology 1664302X 1664302X 10.3389/fmicb.2019.02865

Identifying residues that determine palmitoylation using association rule mining Research Papers in Peer Reviewed Journals Bioinformatics 1367-4803 35 10.1093/bioinformatics/btz003

Molecular Characteristics of “BlaB-like” Chromosomal Inducible Cephalosporinase of Yersinia enterocolitica Biotype 1A Strains Research Papers in Peer Reviewed Journals Microbial Drug Resistance 1931-8448 25 10.1089/mdr.2018.0282

Evaluation of bile salt hydrolases, cholesterol-lowering capabilities, and probiotic potential of Enterococcus faecium isolated from rhizosphere Research Papers in Peer Reviewed Journals Frontiers in Microbiology 1664302X NA 10.3389/fmicb.2019.01567

Molecular analysis of ampR and ampD to understand variability in inducible expression of “BlaB-like” cephalosporinase in Yersinia enterocolitica biotype 1A Research Papers in Peer Reviewed Journals Gene NA 704 10.1016/j.gene.2019.04.031

Antimicrobial resistance and its relationship with biofilm production and virulence-related factors in Yersinia enterocolitica biotype 1A Research Papers in Peer Reviewed Journals Heliyon NA 5 10.1016/j.heliyon.2019.e01777

ampD homologs in biotypes of Yersinia enterocolitica: Implications in regulation of chromosomal AmpC-type cephalosporinases Research Papers in Peer Reviewed Journals Infection, Genetics and Evolution 1567-1348, 1567-7257 69 10.1016/j.meegid.2019.01.033

predicting and classifying betalactamase using a 3-tier prediction system via Chou's general PseAAC Research Papers in Peer Reviewed Journals Journal of Theoretical Biology 0022-5193 457 10.1016/j.jtbi.2018.08.030

Comparative functional analysis of proteins containing low-complexity predicted amyloid regions Research Papers in Peer Reviewed Journals PeerJ 2689-7733 35 10.1093/bioinformatics/btz003

Using molecular-mimicry-inducing pathways of pathogens as novel drug targets Research Papers in Peer Reviewed Journals Drug Discovery Today 1359-6446 24 10.1016/j.drudis.2018.10.010

Prediction of rare palmitoylation events in proteins Research Papers in Peer Reviewed Journals Journal of Computational Biology 0303-6812, 1432-1416 25 10.1089/cmb.2017.0069

HSP70 in Human Diseases and Disorders Research Papers in Peer Reviewed Journals Springer 1877-1246, 978-3-319-89551-2 14 https://doi.org/10.1007/978-3-319-89551-2

Prediction of zinc binding sites in proteins using sequence derived information Research Papers in Peer Reviewed Journals Journal of Bimolecular Structure & Dynamics 4413-4423 36 10.1080/07391102.2017.1417910

miPepBase: A database of experimentally verified peptides involved in molecular mimicry Research Papers in Peer Reviewed Journals Frontiers in Microbiology, section Microbial Immunology 1664-302X 8 https://doi.org/10.3389/fmicb.2017.02053

Proteome-wide prediction and annotation of mitochondrial and sub-mitochondrial proteins by incorporating domain information Research Papers in Peer Reviewed Journals Mitochondrion 15677249 42 10.1016/j.mito.2017.10.004

Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine Research Papers in Peer Reviewed Journals Peer J 2689-7733 NA 10.7717/peerj.3561

MALDI-TOF MS in clinical parasitology: applications, constraints, and prospects Research Papers in Peer Reviewed Journals Parasitology 0031-1820, 1469-8161 143 10.1017/S0031182016001189

PredHSP: Sequence Based Proteome-Wide Heat Shock Protein Prediction and Classification Tool to Unlock the Stress Biology Research Papers in Peer Reviewed Journals PLoS One 1932-6203 NA 10.1371/journal.pone.0155872

CrAgDb – A database of annotated chaperone repertoire in archaeal genomes Research Papers in Peer Reviewed Journals FEMS Microbiology Letters 0378-1097, 1574-6968 363 10.1093/femsle/fnw030

Resistance to amoxicillin-clavulanate and its relation to virulence-related factors in Yersinia enterocolitica biovar 1A Research Papers in Peer Reviewed Journals Indian Journal of Medical Microbiology 0255-0857-1998-3646 34 10.4103/0255-0857.174125

MALDI-TOF mass spectrometry: an emerging technology for microbial identification and diagnosis Research Papers in Peer Reviewed Journals Frontiers in Microbiology 1664302X 6 10.3389/fmicb.2015.00791

Structural Variabilities in β-Lactamase (blaA) of Different Biovars of Yersinia enterocolitica: Implications for β-Lactam Antibiotic and β-Lactamase Inhibitor Susceptibilities Research Papers in Peer Reviewed Journals PLOS One 1932-6203 10.1371/journal.pone.0123564

Low complexity and disordered regions of proteins have different structural and amino acid preferences Research Papers in Peer Reviewed Journals Molecular Biosystems 1742-206X, 1742-2051 11 10.1039/c4mb00425f

Prediction of β-lactamase and its class by Chou's pseudo-amino acid composition and support vector machine Research Papers in Peer Reviewed Journals Journal of Theoretical Biology 0022-5193 365 10.1016/j.jtbi.2014.10.008

CBMAR: a comprehensive β-lactamase molecular annotation resource Research Papers in Peer Reviewed Journals Database 1758-0463 2014 10.1093/database/bau111

NRfamPred: a proteome-scale two level method for prediction of nuclear receptor proteins and their sub-families Research Papers in Peer Reviewed Journals Scientific Reports 2045-2322 10.1038/srep06810

Molecular analysis of β-lactamase genes to understand their differential expression in strains of Yersinia enterocolitica biotype 1A Research Papers in Peer Reviewed Journals Scientific Reports 2045-2322 10.1038/srep05270

Protein sub-nuclear localization prediction using SVM and Pfam domain information Research Papers in Peer Reviewed Journals PLOS One 1932-6203 9 10.1371/journal.pone.0098345

PalmPred: an SVM based palmitoylation prediction method using sequence profile information Research Papers in Peer Reviewed Journals PLOS One 1932-6203 9 10.1371/journal.pone.0089246

Identification of family specific fingerprints in β-lactamase families Research Papers in Peer Reviewed Journals The Scientific World Journal 2356-6140, 1537-744X 2014 10.1155/2014/980572

Analysis of intracellular expressed proteins of Mycobacterium tuberculosis clinical isolates Research Papers in Peer Reviewed Journals Proteome Science 1477-5956 10.1186/1477-5956-10-14

PrionHome: a database of prions and other sequences relevant to prion phenomena Research Papers in Peer Reviewed Journals PLOS One 1932-6203 7 10.1371/journal.pone.0031785

SVM based prediction of RNA-binding proteins using binding residues and evolutionary information Research Papers in Peer Reviewed Journals Journal of Molecular Recognition 0952-3499, 1099-1352 10.1002/jmr.1061

LPS-annotate: complete annotation of compositionally biased regions in the protein knowledgebase Research Papers in Peer Reviewed Journals Database (Oxford) 1758-0463 2011 10.1093/database/baq031

Genomic assessment of the evolution of the prion protein gene family in vertebrates Research Papers in Peer Reviewed Journals Genomics 0888-7543, 1089-8646 95 10.1016/j.ygeno.2010.02.008

Hmrbase: a database of hormones and their receptors Research Papers in Peer Reviewed Journals BMC Genomics 1471-2164 10.1186/1471-2164-10-307

OxDBase: a database of oxygenases involved in biodegradation Research Papers in Peer Reviewed Journals BMC Research Notes 10.1186/1756-0500-2-67

Prediction of polyadenylation signals in human DNA sequences using nucleotide frequencies Research Papers in Peer Reviewed Journals In Silico Biology 13866338, 14343207 9 10.3233/ISB-2009-0395

Prediction of nuclear proteins using SVM and HMM models Research Papers in Peer Reviewed Journals BMC Bioinformatics 1471-2105 10.1186/1471-2105-10-22

CyclinPred: a SVM-based method for predicting cyclin protein sequences Research Papers in Peer Reviewed Journals PLOS One 1932-6203 3 10.1371/journal.pone.0002605

Prediction of RNA binding sites in a protein using SVM and PSSM profile Research Papers in Peer Reviewed Journals Proteins 1097-0134 71 10.1002/prot.21677

COPid: composition based protein identification Research Papers in Peer Reviewed Journals In Silico Biology 13866338, 14343207 8
Identification of DNA-binding proteins using support vector machines and evolutionary profiles Research Papers in Peer Reviewed Journals BMC Bioinformatics 1471-2105 8 10.1186/1471-2105-8-463

Support vector machine based prediction of glutathione S-transferase proteins Research Papers in Peer Reviewed Journals Protein and Peptide Letters 0929-8665, 1875-5305 14 10.2174/092986607780990046

Prediction of mitochondrial proteins using support vector machine and hidden Markov model Research Papers in Peer Reviewed Journals Journal of Biological Chemistry 0021-9258, 1083-351X 281 10.1074/jbc.M511061200

BhairPred: prediction of beta-hairpins in a protein from multiple alignment information using ANN and SVM techniques Research Papers in Peer Reviewed Journals Nucleic Acids Research 0305-1048, 1362-4962 33 10.1093/nar/gki588

Research Projects
Project Title Project Type Year Of Sanction Outcome/Output Duration
Comparative genomics of beta-lactamase genes including in-silico analysis to identify target sequences for beta- lactamase inhibitors Major 2012 30-03-2012 To 29-03-2015 (2 years, 11 months, 27 days)
In-silico protein sequence analysis and function prediction Major 2012 07-07-2012 To 06-07-2015 (2 years, 11 months, 29 days)
In-silico analysis and functional characterization of intergenic regions of ESKAPE pathogens to develop novel drug targets Major 2019 22-07-2019 To 21-07-2022 (2 years, 11 months, 29 days)
Using Dengue virus protein exhibiting molecular mimicry with host proteins as novel drug targets Major 2019 15-09-2019 To 14-09-2022 (2 years, 11 months, 30 days)
Using the National COVID 19 testing databases to develop a machine learning model for rapid prioritization/triage of SARS-CoV2 patients and demographic groups Major 2022 Ongoing since 15-04-2022 (3 years, 2 months, 20 days)
Artificial intelligence-aided genomics, trancriptomics and proteomics analyses of multidrug-resistant enteropathogens to discern novel drug targets Major 2023 Ongoing since 01-02-2023 (2 years, 5 months, 4 days)
National network project of Aligarh Muslim University, Aligarh Major 2023 Ongoing since 14-09-2023 (1 years, 9 months, 21 days)
National network project of Indraprastha Institute of Information Technology Major 2023 Ongoing since 27-12-2023 (1 years, 6 months, 8 days)
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