Title Prof. First Name MAHIMA Last Name KAUSHIK
Designation Professor
Department Cluster Innovation Centre
Email mkaushik@cic.du.ac.in
Webpage
Phone.no 9873036375
Employement Info
Employee Type Nature Of Employment
Teaching Permanent
Educational
Degree/Certification Institution Year
Ph.D. - Multistranded-DNA Ligand Interactions Delhi University 2003
Fellowship
Fellowship Name Fellowship Body Level
post doctorate fellowship University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA International
Research Publications
Article Name Publication Type Journal Name ISSN No Volume Year URL DOI
Temperature induced hyperchromism exhibited by Hoechst 33258: Evidence of drug aggregation from UVMelting method. Research Papers in UGC listed Journals Spectrochimica Acta, Part A 2003 https://doi.org/10.1016/S1386-1425(03)00115-X
Hairpin-Duplex equilibrium reflected in A→B transition in an undecamer quasipalindrome present in locus control region (LCR) of Human -globin gene cluster Research Papers in UGC listed Journals Nucleic Acids Research 2003 DOI: 10.1093/nar/gkg887
Structural polymorphism exhibited by a quasi-palindrome present in the locus control region (LCR) of the human -globin gene cluster Research Papers in UGC listed Journals Nucleic Acids Research 2006 10.1093/nar/gkl456
A study of 7-deaza-2’-deoxyguanosine–2’-deoxycytidine base pairing in DNA Research Papers in UGC listed Journals Nucleic Acids Research 2007 https://doi.org/10.1093/nar/gkm670
Calorimetric unfolding of the bimolecular and i-motif complexes of the human telomere complementary strand, d(C3TA2)4 Research Papers in UGC listed Journals Biophysical Chemistry 2006 https://doi.org/10.1016/j.bpc.2006.05.031
Possibility of an Antiparallel (Tetramer) Quadruplex Exhibited by the Double Repeat of the Human Telomere. Research Papers in UGC listed Journals Biochemistry 2007 https://doi.org/10.1021/bi0621009
Structural transition from dimeric to tetrameric i-motif, caused by the presence of TAA at the 3’-end of human telomeric C-rich sequence Research Papers in UGC listed Journals Biopolymers 1097-0282 93 2009 https://doi.org/10.1002/bip.21313
Structural polymorphism at LCR and its role in beta-globin gene regulation. Research Papers in UGC listed Journals Biochimie 0300-9084 92 2010 https://doi.org/10.1016/j.biochi.2010.04.020
Presence of divalent cation is not mandatory for the formation of intramolecular purinemotif triplex containing human c-jun protooncogene target Research Papers in UGC listed Journals Biochemistry 0006-2960 50 2011 https://doi.org/10.1021/bi1012589
Structural Diversity and Specific Recognition of Four Stranded G-Quadruplex DNA Research Papers in UGC listed Journals current molecular medicine 1566-5240 11 2011 https://doi.org/10.2174/156652411798062421
Advancement in the structural polymorphism of G-quadruplexes Research Papers in UGC listed Journals International review of Biophysical chemistry 2038-0321 5 2014
Exploring Renewable Energy Sources: Need of the hour Research Papers in UGC listed Journals DU J. of UG Research and Innovation 2395-2334 1 2015
Differential structural status of the RNA counterpart of an undecamer quasi- palindromic DNA sequence present in LCR of human β-globin gene cluster Research Papers in UGC listed Journals Journal of Biomolecular Structure and Dynamics 1538-0254 33 2014 https://doi.org/10.1080/07391102.2013.877402
A Bouquet of DNA Structures: Emerging Diversity Research Papers in UGC listed Journals Biochemistry and Biophysics Reports 5 2016 https://doi.org/10.1016/j.bbrep.2016.01.013
Protein engineering and de novo designing of a biocatalyst Research Papers in UGC listed Journals journal of molecular recognition 29 2016 https://doi.org/10.1002/jmr.2546
Interaction of an electrochemical redox indicator New Methylene Blue with DNA using biophysical techniques Research Papers in UGC listed Journals Advanced Materials Proceedings 2002-4428 1 2016 10.5185/amp.2016/108
Exploring the characterization tools of Guanine-quadruplexes Research Papers in UGC listed Journals Frontiers in Bioscience 1093-9946. 21 2016
MicroRNA: A Multi-Facet Biological Target for Cancer and Other Diseases Research Papers in UGC listed Journals Clinical Cancer Drugs 2212-697X 4 2017 https://doi.org/10.2174/2212697X04666170123122037
Multiple dimensions of functional relevance of Genosensors Research Papers in UGC listed Journals Integrated Ferro-electrics 1058-4587 185 2017 https://doi.org/10.1080/10584587.2017.1370349
Structural switch from multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of human GRIN1 gene Research Papers in UGC listed Journals Molecular Biosystems 1742-2051 13 2017 https://doi.org/10.1039/C7MB00360A
Structure-Specific Ligand Recognition of Multistranded DNA Structures Research Papers in UGC listed Journals Current topics in medicinal chemistry 1568-0266 17 2017 10.2174/1568026616666160530154239
Formation of G-wires, bimolecular and tetramolecular quadruplex: Cation induced structural polymorphs of G-rich DNA sequence of Human SYTX gene. Research Papers in UGC listed Journals Biopolymers 0006-3525 109 2018 https://doi.org/10.1002/bip.23115
Structural switch from hairpin to duplex/ antiparallel G-quadruplex at Single Nucleotide Polymorphism (SNP) site of human Apolipoprotein E (APOE) gene coding region. Research Papers in UGC listed Journals ACS Omega 2470-1343 3 2018 https://doi.org/10.1021/acsomega.7b01654
A topological transition from bimolecular quadruplex to G-triplex/ tri-G-quadruplex exhibited by truncated double repeats of human telomere Research Papers in UGC listed Journals European Biophysics Journal 0175-7571 47 2018 10.2174/1568026616666160530154239
Emerging Trends in Advanced Nanomaterials Based Electrochemical Genosensors Research Papers in UGC listed Journals Current Pharmaceutical Design 1381-6128 24 2018 10.2174/1381612824666181109154919
Structural polymorphism of a Cytosine-rich DNA Sequence forming i-motif structure: Exploring pH based biosensors Research Papers in UGC listed Journals International Journal of biological macromolecules 0141-8130 111 2018 https://doi.org/10.1016/j.ijbiomac.2018.01.053
Exploring the DNA Damaging Potential of Chitosan and Citrate-reduced gold nanoparticles: Physicochemical Approach Research Papers in UGC listed Journals International Journal of Biological Macromolecules 0141-8130 115 2018 https://doi.org/10.1016/j.ijbiomac.2018.04.115
Prerequisite of a Holistic Blend of Traditional and Modern Approaches of Cancer Management Research Papers in UGC listed Journals Current Cancer Therapy Reviews 1573-3947 15 2018 10.2174/1573394714666180417160750
Exploring the Potential of DNA/RNA Aptamers in National Security Research Papers in UGC listed Journals National Academy of Science Letters 0250-541X 43 2019 10.1007/s40009-019-00815-z
Physiochemical Interactions of APTS-ZnFe2O4 Nanoparticles with Bovine Serum Albumin (BSA): Biomedical Applications Research Papers in UGC listed Journals Journal of Nanoscience and Technology 2455-0191 5 2019 https://doi.org/10.30799/jnst.242.19050409
Physicochemical Investigations of Zinc oxide Nanoparticles Synthesized from Azadirachta Indica (Neem) Leaf Extract and Their Interaction with Calf-Thymus DNA Research Papers in UGC listed Journals Results in Physics 2211-3797 13 2019 https://doi.org/10.1016/j.rinp.2019.102168
Exploring the potential of environment friendly silver nanoparticles for DNA interaction: Physicochemical approach Research Papers in UGC listed Journals Journal of Photochemistry and Photobiology Part B 1011-1344 194 2019 https://doi.org/10.1016/j.jphotobiol.2019.03.022
Exploring Promises of siRNA in Cancer Therapeutics Research Papers in UGC listed Journals Current Cancer Therapy Reviews 1573-3947 16 2020 https://doi.org/10.2174/1573394715666190207130128
Exploring potential of i-motif DNA formed in the promoter region of GRIN1 gene for nanotechnological applications Research Papers in UGC listed Journals Results in Chemistry 2211-7156. 2 2020 https://doi.org/10.1016/j.rechem.2020.100086
Interaction of a photosensitizer Methylene Blue with various structural forms (cruciform, bulge duplex and hairpin) of designed DNA sequences. Research Papers in UGC listed Journals Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 1386-1425 242 2020 https://doi.org/10.1016/j.saa.2020.118716
Green synthesis and physiochemical characterization of nickel oxide nanoparticles: interaction studies with calf thymus DNA. Research Papers in UGC listed Journals Luminescence (The Journal of Biological and Chemical Luminescence) 1522-7243 35 2020 https://doi.org/10.1002/bio.3709
Exploring potential of i-motif DNA formed in the promoter region of GRIN1 gene for nanotechnological applications Research Papers in UGC listed Journals Results in Chemistry 2211-7156. 2 2020 https://doi.org/10.1016/j.rechem.2020.100086
Self-association of Coralyne: An ordered thermal destacking Research Papers in UGC listed Journals Results in Chemistry 22117156 2 2020 https://doi.org/10.1016/j.rechem.2020.100043
Synthesis and characterization of hydrothermally synthesized superparamagnetic APTS-ZnFe2O4 nanoparticles: DNA binding studies for exploring biomedical application chemical papers 74 2019 https://doi.org/10.1007/s11696-019-00953-0
Hydrothermal Synthesis and Characterization of magnetic Fe3O4 and APTS coated Fe3O4 nanoparticles: Physicochemical investigations of interaction with DNA Research Papers in UGC listed Journals Journal of Materials Science: Materials in Medicine 2020 https://doi.org/10.1007/s10856-020-06405-6
Strategic targeting of non‐small‐cell lung cancer utilizing genetic material‐based delivery platforms of nanotechnology Research Papers in UGC listed Journals Journal of Biochemical and Molecular Toxicology 2021 https://doi.org/10.1002/jbt.22784
Innovative application of facile single pot green synthesized CuO and CuO@APTES nanoparticles in nanopriming of Vigna radiata seeds Research Papers in UGC listed Journals Environmental Science and Pollution Research 2020 https://doi.org/10.1007/s11356-020-11493-6
Designing a two-stage colorimetric sensing strategy based on citrate reduced gold nanoparticles: Sequential detection of Sanguinarine (anticancer drug) and visual sensing of DNA Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2021 https://doi.org/10.1016/j.saa.2020.119039
Gold Nanoclusters: An Ultrasmall Platform For Multifaceted Applications Research Papers in UGC listed Journals Talanta 2021 https://doi.org/10.1016/j.talanta.2021.122623
Structural Switching/polymorphism by sequential base substitution at quasi-palindromic SNP site (G → A), in LCR of Human β-globin Gene cluster Research Papers in UGC listed Journals International Journal of Biological Macromolecules 2022 https://doi.org/10.1016/j.ijbiomac.2021.12.142
Probing multifunctional azure B conjugated gold nanoparticles with serum protein binding properties for trimodal photothermal, photodynamic, and chemo therapy: Biophysical and photophysical investigations Research Papers in UGC listed Journals Material Science and Engineering C 2020 https://doi.org/10.1016/j.msec.2022.112678
Nanopaper Biosensors at Point of Care Research Papers in UGC listed Journals Bioconjugate Chemistry 2022 https://doi.org/10.1021/acs.bioconjchem.2c00213
Exploring the interaction of Guanidine ligands Amiloride, Rimeporide and Cariporide with DNA for understanding their role as inhibitors of Na+/H+ Exchangers (NHEs): A spectroscopic and molecular docking investigation International Journal of Biological Macromolecules 2022 https://doi.org/10.1016/j.ijbiomac.2022.06.009
Interface of G-quadruplex with both stabilizing and destabilizing ligands for targeting various diseases Research Papers in UGC listed Journals International Journal of Biological Macromolecules 0141-8130 219 https://doi.org/10.1016/j.ijbiomac.2022.07.248
Simulation of Nanocarrier Based Targeted delivery of an antidepressant for Major depression disorder (MDD) Research Papers in UGC listed Journals Molecular Simulation 0892-7022 2023
Protein kinases: Role of their dysregulation in carcinogenesis, identification and inhibition Research Papers in UGC listed Journals Drug Research 2194-9379 2023 10.1055/a-1989-1856
Nanomaterials to address the genesis of antibiotic resistance in Escherichia coli Research Papers in UGC listed Journals Frontiers in Cellular and Infection Microbiology 2023 https://doi.org/10.3389/fcimb.2022.946184
Advance nanotherapeutic approach for systemic co-delivery of mitoxantrone loaded chitosan coated PLGA nanoparticles to improve the chemotherapy against human non-small cell lung cancer. Research Papers in UGC listed Journals Journal of Drug Delivery Science and Technology 1773-2247. 2023 https://doi.org/10.1016/j.jddst.2023.104523
Research Projects
Title of the Project Project Type Year Of Sanction Output Start Date End Date
Synthesis, characterization & applications of oligonucleotide conjugated drug loaded polymeric nanoparticles for targeted drug delivery in lung cancer 2021 2021-10-29 2022-06-30
Physicochemical Investigations of the binding interactions of NHE inhibitors (Rimeporide, Amiloride and Cariporide) with APOE3/APOE4 isoforms of human APOE gene 2019 2019-10-01 2022-10-01
Fabrication of an innovative optical/electrochemical nano-biosensor for lung cance using nano-technology 2020 2020-12-31 2021-06-30
Exploring the use of Biocatalysis in laboratory chemical reactions: A Green Chemistry Approach. 2013 2013-11-15 2015-03-30
Holistic Approach of Fighting Cancer: From Prevention to Cure 2015 2015-10-01 2016-10-01
Targeting Oncogenes with Specific Drugs: Exploring Structural Aspects 2015 2015-10-01 2016-10-01
Development of a novel cationic charged polymeric nanoparticle-mediated drug delivery system against Liver Cancer 2022 2022-08-31 2023-05-31
Honour And Awards
Name of the Award Name of the Awarding Body Award Category Level Date of Award
First Poster Prize Nanobioteck-2018, 3rd Annual conference of Indian Society of Nanomedicine, All India Institute of Medical Sciences AIIMS, New Delhi, Delhi Research National 2018-10-24
Second Poster Prize St. Stephens sponsored national conference titled “National Conference on Chemical Science: Opportunities and Challenges Research National 2018-03-20
Third Poster Prize One-day Indo-Hungarian symposium on “Recent advances in chemistry and biology” (INHCAB-2017), Miranda House, Delhi University, Delhi. Research International 2017-12-11
Second Poster Prize Microwave assisted green synthesis of silver nanoparticles using Syzygium Cumini leaf extract: Interaction with Calf thymus DNA Research National 2017-09-28
Second Poster Prize Physicochemical studies of silver nanoparticles prepared using Epipremnum aureum leaves extract with Calf Thymus DNA Research National 2017-09-28
Best Poster Award International Congress on “Friedreich’s Ataxia and DNA Structure in Health & Disease”; All India Institute of Medical Sciences (AIIMS), New Delhi, India. Research International 2015-04-11
Seminar / Conference Details / Workshops
Title of the Activity Attended As Date
Women: An epitome of Strength” in Webinar Session on "The SHE of Science World Invited Talk 2021-03-08
Recent Innovations in Green Technology Invited Talk 2019-09-27
Green Technology: Recent Advances and Challenges Invited Talk 2019-02-14
Exploring Nucleic Acids Based Applications Via Nanotechnology Invited Talk 2018-03-27
Innovative pedagogies Invited Talk 2017-05-02
environmental pollution Invited Talk 2017-05-02
Cancer: facts, figures and awareness Invited Talk 2016-10-04
Alarming and Intertwined Relationship between Cancer and Environmental Pollution Invited Talk 2016-02-19
Environmental Pollution: A Ringing Bell for Cancer Invited Talk 2015-08-24
Emerging Trends in Development of Drugs and Devices Invited Talk 2013-01-21
Resource Person Invited Talk 2012-07-05
Challenges and Opportunities in Chemistry Invited Talk 2006-09-23
Energetic Contributions of C•C+/ C•C+ Base-Pair Stacks to the Formation of Bimolecular Complex and i-motif Structures Invited Talk 2005-02-12
Physicochemical Analysis of the Interaction of Silica and Modified Silica Nanoparticles with Bovine Trypsin for Targeting Biomedical Applications Poster Presentation 2022-04-01
Efficacy of MePEG-PCL Diblock Copolymeric Nanoparticles and PCL Nanoparticles for Drug Delivery in Lung Fibrosis Poster Presentation 2019-05-18
A Physicochemical approach to study and compare the genotoxic potential of chitosan and citrate reduced gold nanoparticles towards calf thymus DNA Poster Presentation 2018-01-12
Multiple dimensions of functional relevance of Genosensors Poster Presentation 2016-11-16
A Physicochemical approach to study the genotoxic potential of chitosan and citrate reduced gold nanoparticles towards calf thymus DNA: A physicochemical approach Poster Presentation 2017-12-11
An environmentally benign approach to synthesize Silver nanoparticles using Epipremnum aureum leaf extract and its interaction studies with Calf Thymus DNA Poster Presentation 2017-12-11
Interaction of an electrochemical redox indicator New Methylene Blue with DNA using biophysical techniques, Poster Presentation 2016-03-01
Structural switch from duplex to cruciform in a quasipalindrome present in promoter region of human otog gene Poster Presentation 2015-04-11
A Novel Parallel Triple Stranded G-Quadruplex Formation In Promoter Region Of Human Myosin  (Myh7) Gene Oral Presentation 2015-04-11
G-Quadruplex polymorphism: An attempt to explore the association between G-tracts and intervening T’s. Poster Presentation 2012-12-08
Self-Association of Coralyne: A Plusible Drawback for DNA targeting. Poster Presentation 2010-01-05
A Study of 7-Deaza-2'-Deoxyguanosine•2'-Deoxycytidine Base Pairing in DNA Poster Presentation 2007-10-24
Structural polymorphism exhibited by the C-rich strand of the Human Telomeric DNA Poster Presentation 2006-01-10
Melting Behavior of DNA Triplexes of the Pyrimidine Motif Poster Presentation 2006-03-29
Stability and Melting Behavior of DNA Triplexes of the Pyrimidine Motif Poster Presentation 2005-06-03
Unfolding of the Complimentary Strand of the Human Telomere. Poster Presentation 2005-06-03
Hemiprotonated CC+ Duplex  i-Motif Equilibrium in the Unfolding of d[C3TA2]4 and d[C3TA2]3C3T Below Physiological pH Poster Presentation 2004-10-09
Unfolding of d[C3TA2]3C3T: Interconversion of the i-motif and Hemiprotonated C.C+ Duplex Below Physiological pH’s. Poster Presentation 2004-08-01
Hairpin-Duplex equilibrium reflected in A→B transition in an undecamer quasi-palindrome present in locus control region (LCR) of Human -globin gene cluster Poster Presentation 2004-01-26
Interaction of polymorphic DNA sequences with intercalants Poster Presentation 2004-01-26
Duplex and Triplex DNA: Stabilization Aspects Poster Presentation 2000-01-26
Regulation of Gene Expression using Antigene Strategy. Poster Presentation 2000-01-26
Colorimetric Assay for rapid detection of Sanguinarine (anticancer drug) and Calf thymus DNA (Ct-DNA) using Gold nanoparticles Oral Presentation 2019-10-04
Exploring the Potential of CuO and CuO@APTES nanoparticles as Nanoprimers to Increase Seed Vigor of Model Legume V. radiata. Oral Presentation 2019-09-26
Comparative analysis of CuO and NiO nanoparticles obtained via green synthesis: For exploring better immobilization, ecotoxicity and photocatalytic degradation of dyes Poster Presentation 2018-10-24
Designing of polymeric nanoparticle drug delivery systems for the treatment of lung fibrosis Poster Presentation 2018-10-24
Characterization, and interactions of NiO nanoparticles synthesized by green method: Applications as Aptasensors Oral Presentation 2018-09-28
Hydrothermal synthesis of magnetite nanoparticles and their interaction with DNA Poster Presentation 2018-02-19
Hydrothermal synthesis of magnetite nanoparticles and their interaction with DNA Poster Presentation 2018-02-19
Hydrothermal synthesis of magnetite nanoparticles and their interaction with DNA Poster Presentation 2018-02-19
Hydrothermal Synthesis, characterization and interaction of 3-aminopropyl-trimethoxysilane (APTS) coated super paramagnetic Fe3O4 nanoparticles with DNA Poster Presentation 2018-03-20
Environment friendly Green Synthesis of NiO Nanoparticles: Characterization and Interaction with DNA; Poster Presentation 2018-02-19
Environment friendly Green Synthesis of NiO Nanoparticles: Characterization and Potential use in Environmental Pollutant Detection& Remediation; Poster Presentation 2018-03-20
Green Synthesis of NiONP, Characterization, interaction with CT-DNA& Potential in Environmental Remediation Oral Presentation 2018-03-22
Green synthesis of Zinc oxide nanoparticles from Azadirachta indica leaf extract and their interaction with Calf thymus DNA Poster Presentation 2017-09-28
Biosynthesized silver nanoparticles from eucalyptus leaf extract and their interaction of Calf Thymus-DNA Poster Presentation 2017-09-27
Unravelling the binding of Calf Thymus DNA with metal nanoparticles: A comparative study of chitosan and citrate stabilized gold nanoparticles Poster Presentation 2017-09-27
Green synthesis of silver nanoparticles using Epipremnum aureum leaf extract and its interaction studies with Calf Thymus DNA Poster Presentation 2017-09-28
Microwave assisted green synthesis of silver nanoparticles using Syzygium Cumini leaf extract: Interaction with Calf thymus DNA Poster Presentation 2017-10-10
Physicochemical Studies of biosynthesized silver nanoparticles and their interaction with Calf-Thymus DNA Poster Presentation 2017-10-10
Physicochemical studies of silver nanoparticles prepared using Epipremnum aureum leaves extract with Calf Thymus DNA Poster Presentation 2017-10-11
Physicochemical study of gold nanoparticles synthesized through Green as well as Chemical method: Interaction with Calf Thymus DNA and the role of stabilizing agent Poster Presentation 2017-10-11
Structural polymorphs of a quasipalindrome located in NEGR1 oncogene Poster Presentation 2015-10-29
Spectroscopic investigation of interaction between ctDNA and New Methylene Blue” Poster Presentation 2015-02-14
Duplex to Cruciform transition in a Quasi palindrome present in Human Neuronal Growth Regulator 1(NEGR1) gene, associated with Cancer Poster Presentation 2015-02-14
Diverse Topology of G-Quadruplexes, Poster Presentation 2013-01-21
G-Quadruplexes: Incredible Topology Poster Presentation 2013-01-13
Self-Association of a ligand: A Cautionary aspect of DNA targeting. Poster Presentation 2010-02-13
Structural Polymorphism exhibited by the C-rich strand of the Human Telomere: Intercalated-motif DNA Poster Presentation 2007-11-15
Formation of a Py●Pu*Pu Type Intermolecular Triplex Containing Human c-jun Protooncogene Sequence Poster Presentation 2007-11-28
Selective Recognition of DNA by Minor Groove Binding Ligands Poster Presentation 2007-11-26
Formation and stability of a DNA triple helical structure at Herpes Virus 4 gene target Poster Presentation 2007-02-01
DNA-Ligand Interactions: Sequence and Structure Selectivity Poster Presentation 2006-11-26
DNA tetraplexes: Interaction with intercalants Poster Presentation 2004-11-21
Structural polymorphism at a quasipalindromic site in -globin gene LCR. Poster Presentation 2004-01-14
Interaction of a minor groove binder Hoechst 33258 with G/C-rich deoxyoligonucleotides Poster Presentation 2003-02-22
Interaction of Proflavine and Acridine Orange with Polymorphic DNA Sequences. Poster Presentation 2001-11-07
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